Neoplasia practical Flashcards

Question 1

Q

Whats wrong with this dog? A sc mass which has been present for years, it has been growing very slowly. Once removed it showed the lump was well demarcated and composed of adipocytes which were normal and there where no mitotic figures found.

Answer

A

Its a lipoma, its benign and the malignant version in liposacroma

Question 2

Q

A dog has a mass which has been present for over a year, but had recently become larger and the surface was ulcerated. the mass was firm and mottled tan to black on the cut section the surface of the mass was ulcerated the dermis contained neoplastic spindle shaped to pleomorphic cells containing variable amounts of melanin. Mitotic figures are common throughout the mass is this mass benign or malignant? what diagnosis will you give? if this neoplasm had a low mitotic rate what would you then name this neoplasm

Answer

A

is this mass benign or malignant? malignant what diagnosis will you give? melanoma if this neoplasm had a low mitotic rate what would you then name this neoplasm benign is less that 3 HFP (mitotic figures) more than 3 is malignant

Question 3

Q

There is a dog with multiple raised and ulcerated skin lesions of variable sizes were present on the ventral side of the abdomen. The lesions are located in the white areas of the skin. There are small masses of epithelial cells which are surrounded bu pronounced fibroblastic response. The neoplastic cell have a high nuclear to cytoplasmic ratio. Some of the neoplastic cells appear squamous in shape and produce small masses of keratin ‘keratin pearls’ What is the diagnosis Is this a benign or malignant neoplasm? What major environment factor is likely to contributed to this neoplasm?

Answer

A

What is the diagnosis squamous cell carcinoma Is this a benign or malignant neoplasm? malignant What major environment factor is likely to contributed to this neoplasm? sunning tanning- UN exposure

Question 4

Q

Name and describe the histological criteria that are used yo distinguish b/w begin and malignant neoplasm (8)

Answer

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Lots of mitotic figures invasion metastasis lots of fibrous tissue lots of variation in morphology werid nucleus poor differentiated cells fast growth

Question 5

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Why do malignant neoplasm often hav large areas of necrosis?

Answer

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adjacent blood vessels can be squished and therefore the blood supply can’t be kept up with

Question 6

Q

A dog has a large red and ulcerated and bleeding skin mass on the ventral abdomen. The lesion is ulcerated and haemorrhapgic surface which is composed of multiple irregular blood spaced lined by neoplastic endothelial cells. the cells exhibit cellular and nuclear pleomorphism and a mitotic rate of 3 per high per field else where the mitotic rate is 1< per high power field. There are areas of blood clots and formation. This is neoplasm malignant or benign and what name would you give this tumour? What name would you give to the benign form of this type of tumour? Where are the 3 main common primary location for these tumours in dogs?

Answer

A

This is neoplasm malignant or benign and what name would you give this tumour? Haemangiosarcoma its malignant What name would you give to the benign form of this type of tumour? Haemangioma Where are the 3 main common primary location for these tumours in dogs? skin spleem right atrium of heart

Question 7

Q

Name is lesion

Answer

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effecting all lung lobes, multifocal, circular, 8mm, black, large, spread of raised black extensive lesions on the lung

Question 8

Q

A sudden growth of multiple masses within the mammary glands with lymph nodes were enlarged. The mammary tissue is infiltrated by multiple lobules of neoplastic epithelial cells. there is large areas of necrosis which is surrounded by collagenous stroma. The neoplastic cells exhibit nuclear and cellular pleomorphism. The mitotic rates range from 8-19 per high power field. Many of the lymphatic vessels and veins contain clumps of neoplastic cells. The lymph nodes also contained masses of metastatic neoplastic epithelial cells what is it? What major routes of spread for malignant neoplasms? In order to metastasise what steps do neoplastic cells need to be able to under in order to spread via blood vessels or lymphatic vessels to another site? (7)

Answer

A

what is it? its a mammary adenocarinoma What major routes of spread for malignant neoplasms? direct sending lymphatics blood vessels In order to metastasise what steps do neoplastic cells need to be able to under in order to spread via blood vessels or lymphatic vessels to another site? 1.detach themselves 2. penetrate basement membrane 3. move through CT or lymphatic tissue 4. invade blood/ lymph vessels 5.invade the immune system 6.attach endothelial surface and move out through basement 7. get blood supply and multiple

Question 9

Q

A male boxer dog has a lump which has been present for a couple of months and had been growing larger. The mass has columns of neoplastic mast cells accompanied by many eosinophils because granules are present, the neoplastic tissue is not well defined. There is a variation in size of neoplastic cells and their nuclei. Mitotic figures are easy to find with many areas having a mitotic rate of 1 per high power field. A toluidine blue stain is often used to assist in identification of granules in the cytoplasm of mast cells. What is the diagnosis? other than surgical excision and histopathology, what is a simple less invasive diagnostic technique that could be used pre-operatively to assist in the diagnosis tumours?

Answer

A

What is the diagnosis? mast cell tumour other than surgical excision and histopathology, what is a simple less invasive diagnostic technique that could be used pre-operatively to assist in the diagnosis tumours? fine need aspire cytology