neoplasia III Flashcards
1
Q
tumor suppressors
A
Growth inh rec. TGFb Growth signal transducers APC Cell cycle regulators RB/E2F, p53, INK4A/p16 apoptosis Fas DNA repair BRCA1 BRCA2
2
Q
oncogene
A
Growth factors (e.g. FGF3) GF receptors GF signal transducers (Ras/abl) Transcriptional activators (myc) Cell cyc. regulators (cycD/cycE)
Survival signals