Neoplasia 3

Question 1

Through what do cancers continue growing?

Answer 1

sustained growth signals

Question 2

What receptor is affected in GI tumours?

Answer 2

C-KIT

Question 3

Ras related tumours can be where?

Answer 3

colon, lung

Question 4

Burkitt lymphoma is mutation in what?

Answer 4

Myc nuclear transcription factor

Question 5

PI3K is targeted at what?

Answer 5

haematological malignancies e.g chronic lymphoma leukaemia

Question 6

What protein is associated with loss of growth inhibition?

Answer 6

p53 anything with prefix p

Question 7

Give another factor that can contribute to growth inhibition?

Answer 7

PTEN

Question 8

What often gives cells unlimited replicative potential?

Answer 8

reactivation of telomerase

Question 9

Switching on what helps cells resist apoptosis?

Answer 9

Bcl-2

Question 10

What growth factor allows cancers to gain own blood supply?

Answer 10

vascular endothelial

Question 11

BCRA can produce tumours where?

Answer 11

breast, ovarian, pancreas

Question 12

Lynch Syndrome is associated with what?

Answer 12

mismatched sequences

Question 13

PD-L1 inhibits what?

Answer 13

t-cell proliferation (apoptosis)

Question 14

Is cancer clonal?

Answer 14

no!!!