Inflammation 3 Flashcards

1
Q

What is infarction?

A

cell death after loss of oxygen

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2
Q

Why does an hypoxic cell cause acute inflammation?

A

cause no oxygen means no ATP which means build up of calcium in cell which stimulates bad things

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3
Q

How long in myocardium infarction before cells are going to die anyway?

A

20 mins

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4
Q

What happens to cells that die hypoxically?

A

necrosis

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5
Q

What are the first sign the cells are going to die?

A

shrink and become red

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6
Q

What is the purpose of neutrophils?

A

phagocytic properties, produce cytokines, associated with acute inflammation

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7
Q

What is coagulative necrosis?

A

cell death with some structures of cells left as ghost outlines before complete phagocytosis

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8
Q

As neutrophils fade away what happens?

A

replaced by macrophages

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9
Q

Is there suppuration in chronic inflammation?

A

no

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10
Q

What does restitution produce?

A

scarring

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11
Q

When macrophages fade away what are they replaced by?

A

fibroblast

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12
Q

What do fibroblasts do?

A

gradually lay down collagen

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13
Q

How long does laying down collagen take to finish?

A

6 weeks

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14
Q

Why is scarring on heart so bad?

A

means that muscle tissue is replaced by scar tissue and can’t pump as well

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