Neoplasia Flashcards
What percentage of Australians die from maligancy? What about cardiovascular disease?
30% and 33% respectively
What does transcoelomic metastasis refer to?
Metatasis into pleural, peritoneal or mediastinal cavity
What cell lineage does adeno refer to?
Glandular
What does carcinoma refer to?
Malignant epithelial cell
Is a benign tumour a cancer?
NO, Cancers are malignant lesions
What histological features do tumours of glandular origins sometimes exhibit?
Glandular lumen
Formation of mucin
Signet ring cells
What histological features do tumours of squamous origins sometimes exhibit?
Keratinisation
Intercalated bridges
Eosinophilic cytoplasm
What types of proteins can carcinogenic mutations effect?
Growth factors
Growth factor receptors
Protein involved in signal transduction
Nucleur-regulatory proteins
Cell cycle regulators
What is the difference between a proto-oncogene and an oncogene?
A oncogene is a mutated form of an proto-oncogene that no longer requires normal growth-promoting signals
What are some common features of malignant tumours?
Locally invasive, destructive growth
Often not well circumsized growth
Frequently induce desmoplasia in stroma they invade
Sometimes have necrosis
Variable differentiation - poor, moderate and well
Potential to metatasize
Define dysplasia
Dysplasia is a general term for abnormal growth (alteration in size, growth or organisation of cells), can is used not only in the context of tumours
How is epigenetic control exerted on TSGs?
DNA is methylated so that the TSG can not be expressed
What are two important factors in angiogenesis?
VEGFs and VEGF-Rs
What is a adenocarcinoma?
Neoplasia of a epithelium of glandular origin
What features do well differentiated cell have?
Resemble their cell of origin well
Low cytological atpyia
Low architectural disorganisation
What cytotic features do neoplasic cells demonstrate?
Larger nuclei
Hyperchromatic nuclei
Pleomorphic nuclei
Prominent necleoli
Coarser nuclear chromatin
More mitosis, abnormal mitotic figures
Architectural disorganisation
What type of genes are BRCA1 and BRCA2?
Genes involved in DNA repair and that are associated with increased risk of breast cancer
What are some common TSGs?
P53, Rb, APC, PTEN
What are some histological features of adenocarcinomas?
They tend to form lumens and attempt to secrete mucus
What are some common features of benign tumours?
Local expansile,
Slow growthing,
Often well circumscribed
Unable to metastasize
Rarely life threatening (unless they’re in a critial position)
Well differentiated cells (ie look like mature cells)
What is a surgical resection
When part or all of an organ is removed to prevent spread of a cancer
Define paraneoplastic effects?
Unusual effects that a tumour produces for unknown reasons and that aren’t normally associated with their cell type.
What is the supposed mechanism of weight loss in cancer patients?
TNF-alpha and IL-1 produced by tumour cells or within their local environment causes an increase in the basal metabolic rate.
What is a lymphona?
Cancer of T or B cells
What are the top 5 most common cancers in Australian women?
Brest
Bowel
Melanoma
Lung
Lymphoma
What types of DNA mutation can occur?
Point mutations
Replication in the number of genes
Chromosomal rearrangements
What features do poorly differentiated cell have?
Do not resemble their cells of origin well
High cytological atypia
High architectural disorganisation
What are some common sites of tumour metastasis?
Liver, Brain, Bone, Lung, LNs