Lou's Pathophysiology Flashcards
Does ventilatory capacity limit healthy people during exercise?
No, HR does
What are the mechanical changes that occur due to pulmonary oedema?
Decrease lung compliance - fluid makes the increases the elastic work of breathing
Decrease lung volume - lungs are harder to expand
Increased airway resistance - due to fluid in the airways
Increased work of breathing (elastic and resistive)
What is the clinical presentation of abestosis?
Progressive breathlessness and cough
Crepitations (the type due to opening of alveolar during inspiration)
Clubbing
+/- Cyanosis
Why is systolic BP lower during inspiration
Negative interthoracic pressure > expands the compliance of pulmonary vasculature > blood pools there > reduces pulmonary return > SV is lower > BP is lower (the body response by increase HR).
What are some causes of increase pulmonary hydrostatic pressure?
Left ventricular failure,
mitral stenosis
fluid overload
pulmonary veno-occlusive disease
What causes pulmonary hypertension?
- Increase LA pressure - eg mitral stenosis, left heart failure
- Increased pulmonary blood flow - eg excess central volume
- Increased pulmonary vascular resistance - eg vasocontriction,
vasculature damage (emphysema), obstruction (PE)
What are 5 causes of hypoventilation?
Motor centre depression
Neuromuscular disease
Chest wall deformities
Obesity
Sleeping disordered breathing
What is MUD?
Medically undiagnosed dyspnoea
Why does obstruction occur during sleep?
- Muscles relax
- Airway is already narrowed (obesity, tonsils)
- Tongue falls back (esp if suprine)
What happens to residual volume with gas trapping?
It increases
Why is a low V/Q match bad?
Hb arrives at alveolar-capillary but isn’t filled with O2 > reduces PaO2 > hypoxaemia
What levels of PaCO2 occur during respiratory failure?
>60mmHg
How thick is the A-C membrane?
0.5 microns
When does diffusion limitation of CO2 occur?
Only if there is very severe diffusion impairment, inadequate ventilation is the primary cause
Generally, conditions that effect the alveolar membrane make the lungs …
Stiffer - increasing the elastic work of breathing
Except in Emphysema
How does metabolic acidiosis occurs due to pulmonary oedema?
Pulmonary oedema (=low gas exchange) therefore tissue hypoxia - anaerobic resp. - lactic acid - metabolic acidosis.
What physiological differences are present when breathing with an obstruction?
Active exhalation
Slower inhalation and exhalation
Reduction in maximum ventilation
Increased work of breathing/use of respiratory muscles
Increased sensation of breathing
What does anxiety do to the respiratory equilibrium?
Anxiety > hyperventilation > PaCO2 drop > pH Increases = Respiratory alkalosis
What diseases can disrupt the A-C membrane?
Infections - TB, pneumonia
Pneumonitis (inflammation of the alveoli) eg drug induced
Pulmonary fibrosis
Emphysema
Oedema
Lymphangitis
Carcinomatosis
What happens to maximum ventilation in restrictive lung disease?
It decreases
What is type I respiratory failure characterized by?
Low PaO2
What is type II respiratory failure characterised by?
PaCO2 >50mmHg and PaO2 low to normal
due to failure of ventilation
What is the normal lymphatic flow rate in the lung?
20ml/hour
What factors determine the compliance of the lungs?
Tissue composition
Surfactant
True or false, ventilation rate is higher dependent of PaO2?
False, PaO2 must drop below 60 before there is a response
What are the gas exchange changes that occur due to pulmonary oedema?
hypoxaemia due to shunt
Low V/Q units
Diffusion impairment