Neonatology Flashcards

1
Q

[Neo/Basic]

Preterm/term baby differentiating gestational week

A

37 week
(≥ 37 weeks term, ≤36 weeks and 6 days preterm)

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2
Q

[Neo/Basic]

Categories and gestational ages for preterm baby?

Extreme: ___
Very: ___
Moderate: ___
Late: ___

A

Extreme preterm: < 28 weeks
Very preterm: 28 weeks ≤ and < 32 weeks
Moderate preterm: 32 weeks ≤ and < 34 weeks
Late preterm: 34 weeks ≤ and < 37 weeks

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3
Q

[Neo/Basic]

Categories and gestational age for term baby?

Early: ___
Full: ___
Late: ___
Post: ___

A

Early term: 37 weeks ≤ and < 39 weeks
Full term: 39 weeks ≤ and < 41 weeks
Late term: 41 weeks ≤ and < 42 weeks
Post term: ≥ 42 weeks

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4
Q

[Neo/Basic]

Categories for low birth weight?

Extremely low: ___
Very low: ___
Low: ___

A

Extremely low birth weight: < 1000 g
Very low birth weight: 1000 g ≤ and < 1500 g
Low birth weight: 1500 g ≤ and < 2500 g

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5
Q

[Neo/Basic]

Dates of cleavage and chorion/amnion structures of twin

Morula (___ days) -> chorion/amnion (fraternal/identical)
Blastocyst (___ days) -> chorion/amnion (identical)
Implanted blastocyst (___ days) -> chorion/amnion (identical)
Formed embryonic disc (___ days) -> chorion/amnion (identical)

A

Morula (1-3 days) -> Dichorion/Diamnion (fraternal/identical)
Blastocyst (4-8 days) -> Monochorion/Diamnion (identical)
Implanted blastocyst (8-13 days) -> Monochorion/Monoamnion (identical)
Formed embryonic disc (13-15 days) -> cojoined twins (identical)

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6
Q

[Neo/Prenatal]

Prenatal schedule and purpose:

6-8 weeks: ___
10-14 weeks: ___
16-20 weeks: ___
22-26 weeks: ___
28 weeks: ___
32 weeks, 36 weeks, weekly after: ___

A

Prenatal schedule and purpose:

6-8 weeks: 1st prenatal visit and labs
10-14 weeks: fetal heart tones
16-20 weeks: blood work for NTD and chromosomal abnormalities, anatomic scans
22-26 weeks: routine return visit
28 weeks: glucose tolerance test, repeat CBC, Rh immunoglobulin
32 weeks, 36 weeks, weekly after: GBS at 36w ≤ < 38w

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7
Q

[Neo/Prenatal/GBS]

Prophylaxis indication for GBS (6)

A
  1. Previous history of infant with invasive GBS disease
  2. Positive GBS bacteriuria during any trimester of current pregnancy
  3. Positive GBS culture or NAAT positive (unless C-section before labor)
  4. < 37 weeks of gestation (Before GBS test at 36)
  5. ≥ 18 hours of rupture of membrane
  6. Mother fever 100.4 F
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8
Q

[Neo/Prenatal/GBS]

Prophylaxis choice if allergic to penicillin for GBS prophylaxis?

Low risk for anaphylaxis: ___
High risk for anaphylaxis: ___
High risk and resistant: ___

A

Low risk for anaphylaxis: Cefazolin
High risk for anaphylaxis: Clindamycin
High risk and resistant to clindamycin: Vancomycin

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9
Q

[Neo/Prenatal/PROM]

Delivery is recommended in PROM

if ____ is confirmed
and
gestational age is ___

A

Delivery is recommended in PROM

if _FETAL LUNG MATURITY _is confirmed
and
gestational age is ≥ 34 WEEKS

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10
Q

[Neo/Prenatal/Preeclampsia]

Symptoms of hypermagnesemia in newborn (4)

Lab value Mg > ___ mg/dL

A

Lab value Mg > 5 mg/dL

  1. Respiratory depression
  2. Failure to pass meconium
  3. Lethargy, flaccidity, hyporeflexia
  4. Poor feeding
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11
Q

[Neo/Prenatal/Preeclampsia]

Treatment of hypermagnesemia in newborn

A

IV Ca2+ and diuresis

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12
Q

[Neo/Prenatal/Preeclampsia]

Laboratory findings of newborn from preeclampsia mother (3)

A
  1. Hypermagnesemia
  2. Low WBC
  3. Low Platelet
    (all three are often transient)
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13
Q

[Neo/Prenatal/BPP]

Biophysical profile measurements at 32 and 36 weeks
Mneumonic:
M
R
H
A
T

A

Movement
Respiration
Heart rate reactivity
Amniotic fluid volume
Tone

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14
Q

[Neo/Delivery]

Weight and endotracheal tube size

< 1 kg: __
1-2 kg: __
> 2 kg: __

A

Weight and endotracheal tube size
< 1 kg: 2.5 mm
1-2 kg: 3.0 mm
> 2 kg: 3.5 mm

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15
Q

[Neo/Delivery]

Formula for length of tube to the baby’s lip

A

6 + weight in kg

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16
Q

[Neo/Delivery]

Epinephrine dose for neonatal resuscitation

IV: __
ET: __

A

IV: 0.02 mg/kg, 0.2 ml/kg of 1:10,000 epinephrine
ET: 0.1 ml/kg

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17
Q

[Neo/Delivery]

Which GA to use plastic wrap for resuscitation

A

< 29 weeks

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18
Q

[Neo/GA]

180 degree heel to ear
Sticky, friable, transparent skin
No lanugo
Imperceptible breast
Flat, smooth scrotum or prominent clitoris, flat labia

A

20 weeks

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19
Q

[Neo/GA]

Posture limbs extended
Gelatinous, red, translucent skin
Sparse lanugo
No plantar crease
Empty scrotum, faint rugae, or prominent clitoris and small labia minora

A

24 weeks

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20
Q

[Neo/GA]

Posture flexed on wrists and knees
Skin smooth, pink, visible veins
Abundant lanugo
Faint plantar crease
Flat areola, no bud
Slow recoil of ears
Tests in upper inguinal canal, rage rugae, or prominent clitoris, enlarging minora

A

28 weeks

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21
Q

[Neo/GA]

Posture flexed mildly on elbows and knees
Positive scarf sign, elbow at the midline
Skin superficial peeling, few veins
Thinning of lanugo
Plantar anterior transverse crease only
Stippled areola, no breast buds
Well curved pinna, soft, ready recoil ears
Testes descending, few rugae or majora and minora equally prominent

A

32 weeks

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22
Q

[Neo/GA]

Posture flexed
Negative scarf sign
Skin cracking pale areas, rare veins
Bald areas of lanugo
Plantar creases anterior 2/3
Raised areola, 1-2 mm breast buds
Formed and firm ears, instant recoil
Testes descended, good rugae, or majora large, minora small

A

36 weeks

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23
Q

[Neo/GA]

Posture flexed
Skin with parchment, deep cracking, no vessels
Almost no lanugo
Plantar creases over the entire sole
Full areola, 7-10 mm breast buds
Thick cartilage, stiff ears
Deep rugae or majora covers clitoris and minora

A

40 weeks

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24
Q

[Neo/Neonatal conjunctivitis]

Neonatal conjunctivitis usual onset and its treatment?
Neisseira: ___ days, treatment: ___
Chlamydia: ___ days, treatment: ___

A

Neisseria: 3-5 days, treatment: 3rd gen cephalosporin, prevented by topical erythromycin ointment

Chlamydia: 5-12 days, treatment: PO erythromycin or azithromycin

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25
# [Neo/Normal Newborn] Periodic breathing patterns of neonate is predominant at ____ age resolves by ___ age normal periodic breading if lasts ___ sec
Periodic breathing patterns of neonate is predominant at 2-4 weeks age resolves by 6 mo age normal periodic breading if lasts <20 sec
26
# [Neo/Normal Newborn] Diastais recti surgical indication If hernia persists till ___ age or size increases between ___ and ___ age
Diastais recti surgical indication If hernia persists till 5-6 age or size increases between 1 and 2 age
27
# [Neo/Maternal exposure] Which teratogenic drugs? Diagnosis? Growth deficiency, developmental delays, craniofacial anomalies, _hypoplastic nails_
Phenytoin Fetal hydantoin syndrome
28
# [Neo/Maternal exposure] High risk of congenital anomaly caused by carbamazepine or valproic acid (2)?
Spina bifida Neural tube defects
29
# [Neo/Maternal exposure] Which teratogenic drugs? Limb anomalies, ear malformation with deafness Medication used for leprosy, HIV, multiple myeloma
Thalidomide
30
# [Neo/Maternal exposure] Which teratogenic drugs? Craniosynostosis, craniofacial anomalities, limb defects
Methotrexate
31
# [Neo/Maternal exposure] Which teratogenic drugs? Cardiac defects, Neural tube defects, Renal dysgenesis, oligohydramnios, pulmonary hypoplasia, limb defects, _Skull ossification defects_
Angiotensin-converting enzyme inhibitors (ACEis)
32
# [Neo/Maternal exposure] Which teratogenic drugs? Uterine abnormalities, vaginal adenosis, male infertility
Diethylstilbestrol (DES)
33
# [Neo/Maternal exposure] Which teratogenic drugs? Ebstein anomaly, congenital heart block
Lithium
34
# [Neo/Maternal exposure] Which teratogenic drugs? Similar to DiGeorge syndrome, Microcephaly, facial nerve palsies, microtia, external auditory canal anomalies, cardiac defects, thymic hypoplasia, GU anomalies
Retinoids
35
# [Neo/Maternal exposure] Streptomycin causes ____ in infant
Hearing loss
36
# [Neo/Maternal exposure] Which teratogenic drugs? _Tooth discoloration_ Growth defect
Tetracyclin
37
# [Neo/Maternal exposure] Which teratogenic drugs? Nasal hypoplasia Stippled epiphyses
Warfarin
38
# [Neo/Maternal exposure/FAS] Fetal alcohol syndrome diagnosis criteria (3)
All three categories 1. Facial abnormality, 2 of the following Shortened palpebral fissures Epicanthal folds Hypoplastic nasal root Short, upturned nose Hypoplastic or absent philtrum Thin upper lip Midface hypoplasia 2. Pre- or postnatal growth deficiency, 1 of the following Weight < 10th percentile Microcephaly Length-to-height ratio < 10th percentile 3. Cognitive abnormality
39
# [Neo/Maternal exposure/Mercury] Characteristics of newborns with mercury exposure?
Cerebral atrophy, seizures, developmental delay
40
# [Neo/Maternal exposure/Substance] Which substance abuse? Miscarriage, still birth, premature delivery Placental abruption Intracranial hemorrhage Newborn abstinence syndrome: jitteriness, irritable, tremulous, rigidity, short half life
Cocaine
41
# [Neo/Maternal exposure/Substance] Which substance abuse? Miscarriage, still birth, prematurity Low birth weight _Risk for sudden infant death_
Cigarette
42
# [Neo/Maternal Medical condition] What is mother’s medical condition? Still birth, prematurity Congenital heart block, cardiomyopathy, structural anomalies Rash (raccoon eyes) Elevated LFT, hepatosplenomegaly Cytopenia
Systematic lupus erythematosus (SLE) (Neonatal lupus)
43
# [Neo/Cong Infection] Which prenatal infection? Severe anemia, heart failure, hydrops fetalis
Human parvovirus B19
44
# [Neo/Cong Infection] Which prenatal infection? IUGR Limb reduction defects Microphthalmia, chorioretinitis, _skin scarring_ Microcephaly
Varicella
45
# [Neo/Cong Infection] Which prenatal infection? IUGR Microcephaly _Periventricular calcifications_ Hearing loss Intellectual disability
Cytomegalovirus (CMV) (Toxo parenchymal calcification, CMV CircuMVent calcification)
46
# [Neo/Cong Infection] Which prenatal infection? Blueberry muffin rash Up to 8 weeks: deafness 9-12 weeks: cataracts 12-30 weeks: heart defects
Rubella
47
# [Neo/Cong Infection] Which prenatal infection? Hydrocephalus Choreoretinitis _Parenchymal cerebral calcification_ Hepatosplenomegaly Intellectual disability
Toxoplasmosis (Toxo parenchymal calcification, CMV CircuMVent calcification)
48
# [Neo/Cong Infection] Which prenatal infection? Abnormal teeth/bones, intellectual disability, Hutchinson triad (Teeth, cranial nerve 8 palsy, interstitial keratitis)
Syphilis
49
# [Neo/Cong Infection/Syphilis] Treatment for Category 1 (highly likely: abnormal newborn finding, ≥ 4 fold in VDRL or RPR) And Category 2 (less likely: <4 fold in VDRL or RPR and normal PE, mother was not treated)
Category 1 IV Penicillin G for 10 days Category 2 Penicillin G IM one dose
50
# [Neo/Cong Infection/Syphilis] Newborn investigation for Category 1 (highly likely: abnormal newborn finding, ≥ 4 fold in VDRL or RPR) And Category 2 (possible: <4 fold in VDRL or RPR and normal PE, mother was not treated)
Category 2 CSF for VDRL, cell count, protein CBC Long bone x-rays Category 1 Plus LFT, Chest x-ray, head ultrasounds, eye/hearing exam
51
# [Neo/Cong Infection/Syphilis] Criteria for Category 3 (less likely) and category 4 (unlikely)
Category 3 Normal newborn finding AND Titer < 4 folds AND Treated at least > 4 weeks before delivery -> one time Penicillin G IM Category 4 AND treated before pregnancy AND titer remained low during pregnancy -> no treatment
52
# [Neo/Cong Infection/Syphilis] Investigation and treatment for Category 3 (less likely: treated before delivery, normal titer) Category 4 (unlikely: treated before pregnancy, remained low titer)
Category 3 No newborn investigation Penicillin G IM once Category 4 No investigation, no treatment
53
# [Neo/neonatal sepsis] Invasive GBS sepsis treatment? Early onset: __ Late onset: __
Early onset: Penicillin G Late onset: ampicillin and cefotzime or ceftazime (≤28 days), or ceftriaxone ( >28 days)
54
# [Neo/Maternal exposure] Which teratogenic drugs? _Persistent pulmonary hypertension_ neonatal withdrawal, prematurity, low birth weight
Selective Serotonin Reuptake inhibitor (SSRI)
55
# [Neo/Perinatal injury] Klumpke injury Which nerve involvement? Horner syndrome, anisocoria, harlequine sign
T1 involvement: Horner Klumpke injury (C7-T1)
56
# [Neo/GA] Maximum vernix coverage at ____ weeks
37 weeks
57
# [Neo/GA] Absent breast tissue till ___ weeks Raised areola at ___ weeks
No breast till 33 weeks Raised areola 34 weeks
58
# [Neo/GA] Ear well defined incurving to lobe at ___ weeks
39
59
# [Neo/GA] 1-2 anterior sole crease at ___ weeks
32 weeks
60
# [Neo/GA] Lanugo covers entire body till ___ weeks Absent from the fact at ___ weeks
Full lanugo at 32 weeks No face lanugo at 34 weeks
61
# [Neo/GA] Lanugo disappears from the face between ___ and ___ weeks
32 to 37 weeks
62
# [Neo/GA] Testicles palpable upper scrotum between ___ and ___ weeks
36 and 39 weeks
63
# [Neo/Newborn finding] Diagnosis? Infants followed by birth injury, hypoxia, meconium aspiration, forceps delivery Self-limited 6-8 weeks Hypercalcemia during the first 6 months
Subcutaneous fat necrosis
64
# [Neo/Cong infection] Name of congenital infection? Transverse bands of indreased density across metaphyses Patchy areas of bony destruction in the diaphysis Periosteal new bone formation
Congenital syphilis
65
# [Neo/Maternal exposure/FAS] Congenital anomalies commonly seen in fetal alcohol syndrome (FAS)? (2)
Cardiac septal anomalies (VSD) Minor joint and limb anomalies
66
# [Neo/TTTS] Twin to twin transfusion syndrome Donor child CBC: ___ Amniotic fluid: ___ Recipient child CBC: ___ Amniotic fluid: ___
Donor child CBC: anemia Amniotic fluid: oligohydramnions Recipient child CBC: polycythemia, hyperbilirubinemia Amniotic fluid: polyhydramnios
67
# [Neo/Cong anomaly] Most common site for congenital diaphragmatic hernia?
Left, posterolateral defect
68
# [Neo/Cong infection] Which prenatal infection? 3-7 days of life Myocarditis Fulminant hepatitis Encephalitis/meningitis
Enterovirus: coxsackievirus, enterovirus,
69
# [Neo/Cong infection] Which prenatal infection? Microcephaly Seizure Arthrogryposis Sensorineural hearing loss
Zika virus
70
# [Neo/neonatal spesis] Which bacteria? Preterm birth Pneumonia Septicemia Granulomatosis infantisepticum (erythematous rash with papules)
Listeria