Emergency Medicine Flashcards
[EM/Toxicology]
Categories of drug for ‘excited’ (agitation, hypertension, tachycardia, hyperventilation, hyperthermia, mydriasis) (3)
- Anticholinergics (antihistamin, TCA, atropine)
- Sympathomimetics (pseudoephedrine, cocaine, amphetamine)
- Hallucinogens (LSD, Psilocybin)
[EM/Toxicology]
Categories of drugs for ‘depressed’ (obtundation, hypotension, bradycardia, hypoventilation, hypothermia, miosis) (4)
- Cholinergics (organophosphate, insecticides)
- Sympatholytics (clondine)
- Opiates (oxycodone)
- Sedative-hyponitcs (BZ, barbiturates)
[EM/Toxicology]
Anticholinergic toxidrome (7)
Dry, flushed skin
Hyperthermia
Mydriasis
Agitation, delirium, hallucinations
Urinary retention, decreased bowel sounds
Tachycardia, hypertension
[EM/Toxicology]
Cholinergic toxidrome (7)
D
U
M
B
E
L
S
Diarrhea
Urination
Miosis
Bronchorrhea, bronchospasm, bradycardia
Emesis
Lacrimation
Salivation
[EM/Toxicology]
Which toxidrome?
Muscle weakness, fasciculation, paralysis
Respiratory depression, lethargy, seizures, coma
Bradycardia
After Insecticides (organophosphate/carbamate) ingestion
Nicotinic toxidrome
[EM/Toxicology]
Which toxidrome?
CNS depression
Miosis
Respiratory depression/apnea
Bradycardia, hypotension
Opioid toxidrome
[EM/Toxicology]
Which toxidrome (class)?
Agitation, tremors, hallucinations, seizures
Tachycardia, hypertension
Mydriasis
Ingestion of
Pseudoephedrine
Psychostimulants, cocaine, amphetamines
Sympathomimetic toxidrome
[EM/Toxicology]
Which agent?
Sympathomimetic toxidrome (agitation, tachycardia, mydriasis)
With vertical nystagmus, miosis
PCP (Phencyclidine)
[EM/Toxicology]
Examples of anticholinergics (5)
- Antihistamin
- Neuroleptics (chorpromazine, quetiapine)
- Tricyclinc antidepressants
- Atropine
- Antispasmodics (hyoscyamine)
[EM/Toxicology]
Examples of sympathomimetics (5)
- Ephedrine
- Dextromethorphan
- Cocaine
- Amphetamine/methamphetamine
- MDMA (ecstasy)
[EM/Toxicology]
Examples of hallucinogens (3)
- LSD
- PCP
- Mescaline, psilocybin
[EM/Toxicology]
Examples of cholinergics
Insecticides (organophosphate, carbamate)
[EM/Toxicology]
Examples of sympatholytics (1)
Clonidine
[EM/Toxicology/Sadatives]
Examples of sedative-hypnotics (2)
Benzodiazepines
Barbiturates
[EM/Toxicology/AAP]
Acetaminophen minimal toxic dose is
___ mg/kg in < 12 years old
___ g in adults
150 mg/kg in < 12 years old
7.5 g in adolescent/adults
[EM/Toxicology/AAP]
Symptoms of acetaminophen toxicity
Stage 1 (0-24 hours): ___
Stage 2 (1-3 days): ___
Stage 3 (3-4 days): ___
Stage 4 (4-14 days): ___
Stage 1 (0-24 hours): nausea/vomiting, normal LFT
Stage 2 (1-3 days): RUQ pain, Increased LFT, PT/INR
Stage 3 (3-4 days): fulminant hepatic failure, coagulopathy
Stage 4 (4-14 days): recovery or death
[EM/Toxicology/AAP]
Treatment of acetaminophen toxicity
If less than 1 hour: ___
If toxicity is possible: ___
If less than 1 hour: activated charcoal
If toxicity is possible: NAC (N-acetylcysteine)
[EM/Toxicology]
Which ingestion?
Treatment?
Tinitus
GI: Nasuea/vomiting
Respiratory: tachypnea, respiratory alkalosis
Metabolic: anion gap acidosis,
CNS: agitation, coma
Salicylate ingestion
- Treatment:
Alkalinization with sodium bicarbonate
[EM/Toxicology]
Which class drug ingestion and treatment?
Bradycardia, hypotension, ventricular dysrhythmias
Hypoglycemia
Antihypertensives (b-blocker)
(If HYPERglycemia, CCB)
Treatment:
Glucagon
Vasopressor
[EM/Toxicology]
Which class drug ingestion and treatment?
Bradycardia, hypotension, ventricular dysrhythmias
Hyperglycemia
Calcium channel blocker
(HYPOglycemia: b-blocker)
Treatment:
Calcium gluconate