Nematodes of Dogs, Cats, and Humans Flashcards
Toxocara cati
Common roundworm of small intestine of kittens
Morphology:
Long, white, straight
Cervical alae arrowhead shaped
Males 6 cm long; females 12 cm long
Egg:
Similar to T. canis, but slightly smaller
Toxocara Cati Life Cycle
Transmammary transmission
Primary route of infection for kittens
Direct transmission
Ingestion of infective eggs
Ingestion of paratenic hosts
More important in cats, since they are hunters
Transplacental transmission
DOES NOT OCCUR
Toxocara Cati Clinical Signs
Usually asymptomatic
No migration when acquired through milk, so pneumonia rare
May cause pot-bellied appearance, dull hair coat, vomiting, diarrhea or constipation
Rarely, intestinal obstruction or rupture
Toxocara Cati diagnosis and control
Diagnosis:
Adult worms in feces or vomitus
Eggs on fecal flotation
Control:
Most feline dewormers effective – deworm at 2-3 weeks of age and repeat at least once
Public health significance:
Same as T. canis, but more rare
Toxascaris Leonina
Small intestinal roundworm of dogs/cats
Less common
Morphology:
Smaller than T. cati; lancelet shaped cervical alae
Egg:
Oval, shell smooth on outside, pitted on inside
Lighter in color than Toxocara eggs
Toxascaris Leonina (Life cycle and transmission)
Under optimal conditions, eggs embryonate and become infective in 1 week. After ingestion, eggs hatch and larvae migrate into the intestinal wall, where 2 molts occur. No other migration occurs.
Ingestion of paratenic hosts OR intermediate hosts (because a larval molt occurs in them – to L3).
IHs include mice, rabbits and chickens
Toxascaris Leonina (Clinical Signs)
Least pathogenic ascarid
Usually no clinical signs
Severely infected may show abdominal pain, vomiting, diarrhea, and occasional death.
Dogs and cats do not develop immunity; therefore, may find adult worms in adult pets.
Toxascaris Leonina (Diagnosis and control)
Diagnosis:
Eggs in feces
Worms in feces or vomitus
Control:
Same as for Toxocara sp.
Public Health Significance:
None
Ascaris lumbricoides
Largest nematode parasitizing human intestine
Associated with poor socioeconomic conditions
Approximately 25% world’s population infected
Low mortality, but causes about 20,000 deaths/year worldwide
Ascaris Lubricoides (morphology)
Morphology:
Typical ascarid
Females up to 50 cm long; males up to 30 cm
Tail of male coils ventrally
Male has a pair of short, curved, distally pointed spicules
Eggs:
Ovoid, thick mamillated shell
Female may lay 200,000 eggs/day – up to 73,000,000 during its lifetime
Ascaris Lumbricoides (clinical signs)
Pulmonary signs vary from slight cough to severe pneumonia
May emerge spontaneously from mouth, nose, or anus
May obstruct bile or pancreatic duct
Interfere with host absorption of nutrients
Acute abdominal problems, such as perforated intestinal wall or intestinal obstruction
Allergic reactions result in facial edema, conjunctivitis, and occasionally severe asthma
Hookworm Genuses
Ancylostoma, Ucinaria, Necator
Hookworm morphology
Morphology
Reddish brown, 6-20 mm long
Females larger; males have bursa
Teeth or cutting plates on ventral rim of mouth opening – up to 4 pairs
Eggs
Oval, thin-shelled, segmented
Release L1 larvae in 24-48 hours
Uncinaria & A. braziliense eggs larger
Hookworm Life Cycle
Life Cycle – Routes of Infection
Direct – Ingestion of free-living L3
Develop in small intestine – usually no migration
Percutaneous
Penetrate the skin and migrate through the circulatory system into the lungs, trachea, esophagus, stomach, and small intestine, where they mature
Some larvae encyst in skeletal muscle in dormant stage (hypobiotic larvae)
Transplacental
Transmammary
Via milk for 1st 3 weeks lactation
Primary route for puppies
Hookworm Clinical Signs
Bloodsuckers
Take in small plug intestinal mucosa/capillaries
Secrete an anticoagulant
Blood passes thru worms during feeding & is wasted
Feeding sites continue to bleed after worm moves to another site
Signs are related to anemia that develops
Prenatally infected pups – high mortality rate at 2.5 - 4 weeks
Older pups/dogs – poor doers; dark, tarry diarrhea, pale mucous membranes, etc.
Hookworm Control
<u>Therapy</u>
Deworming at 2, 4, 6 weeks of age or more often if necessary
Blood transfusion if blood loss severe
<u>Diagnosis</u>
Clinical signs
Eggs in feces
<u>Control</u>
Preventatives
Drying, direct sunlight kill L3s
Dirt pens get heavily contaminated
Hookworms for humans
Public health significance
Pet hookworms, especially A. braziliense, cause cutaneous larval migrans in people – called “ground itch.” L3 larvae penetrate skin, but do not develop further
Human hookworms
Hundreds of millions infected
Daily blood loss estimated = total blood volume of 1,500,000 people
Route of infection percutaneous
Control: health education, sanitary latrines, wearing of shoes, and dewormer treatment
Whipworms
Dogs: Trichuris vulpis
Cats: very rare
Humans: Trichuris trichuria
Morphology:
45-75 mm long
Long, thin anterior end; short, thick posterior end
Males have tightly coiled tails with one long, slender spicule enclosed in a sheath
Anterior end has a small sharp point to penetrate mucosa
Whipworm life cycle
Direct: Eggs become infective in about 2 weeks under ideal conditions ingested by host larvae emerge through operculae mature in intestine adults live in cecum (appendix) or colon (large intestine)
Prepatent period approximately 3 months
Whipworm diagnosis
Diagnosis:
Eggs on fecal flotation
Often requires serial fecal exams – eggs shed intermittently
Clinical signs
Usually mild
Diarrhea (often greenish), emaciation, dehydration, anemia, and occasionally death may be seen in young
In older dogs, intermittent greenish diarrhea with occasional mucus or fresh blood is the most common sign
Rarely rectal prolapse, esp. in humans
Threadworms
Strongyloides stercoralis
humans, dogs, cats, foxes
Strongyloides tumefaciens
cats
Morphology:
2 mm long
Only females are parasites of small intestines
Eggs:
Small, embryonated
S. stercoralis eggs
Threadworm Life Cycle
Life Cycle
L1 larvae may
Develop into infective L3s
Develop into non-parasitic male and female free-living nematodes that produce infective larvae
Therefore, “facultative” parasites
Transmission is percutaneous – L3 enters skin circulation lung (L4) trachea gut (L5); also occasionally oral ingestion of L3s with same migratory route
Young animals – larvae stored in tissue adjacent to mammary glands activated during gestation milk
Threadworm clinical signs
Most often seen in tropics, where is a disease of kenneled dogs
Enteritis
GI hemorrhage
Diarrhea
Pruritus from skin penetration
Verminous pneumonia from migration
Diagnosis
L1 larvae in direct smears or flotation for S. stercoralis
Embryonated eggs in fecal exams for S. tumefaciens
Threadworm control
Control
Larvae susceptible to drying
If possible, clean kennel, vacate, and leave dry for 3 weeks
Public health significance – human infections
Varies from asymptomatic carriers to fatal disseminated infection in immunosuppressed persons, such as those with AIDS; causes “swollen baby (belly) syndrome“ in New Guinea – fatal unless rapidly treated