Nelson - Ch. 200 E. coli Flashcards

1
Q

E.coli ?aerobic ?gram ?lactose

A

Facultative anaerobic, G-, lactose fermenter

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2
Q

T/F Most fecal E.coli cause diarrhea

A

F, do not cause

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3
Q

Most diarrheagenic E.coli except ___ require a large inoculum of organisms to induce disease

A

STEC

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4
Q

MCC of traveler’s diarrhea

A

ETEC

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5
Q

Accounts for 10-30% of dehydrating infantile diarrhea

A

ETEC

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6
Q

Enterotoxin produced by ETEC associated with increased risk of death

A

ST-ETEC or heat stable enterotoxin

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7
Q

ETEC diarrhea is self-limited and resolves in

A

3-5 days, occasionally longer than 1 week

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8
Q

ETEC enterotoxin that is structurally, functionally, and immunologically related to cholera toxin produced by V. cholerae

A

LT or heat labile toxin

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9
Q

ETEC enterotoxin: Large molecule

A

LT

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10
Q

ETEC enterotoxin: Small molecule

A

ST

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11
Q

ETEC enterotoxin: Stimulates adenylate cyclase –> increased CAMP

A

LT

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12
Q

ETEC enterotoxin: Stimulates guanylate cyclase –> increased CGMP

A

ST

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13
Q

Genes for ST and LT of ETEC are encoded on

A

Plasmids

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14
Q

E. coli: Explosive, nonmucoid, nonbloody diarrhea, little or no fever

A

ETEC

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15
Q

E. coli: Resembles bacillary dysentery since it shares virulence genes with Shigella spp

A

EIEC

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16
Q

E. coli: Cause colonic ulcerations, hemorrhage, mucosal and submucosal edema, and infiltration by PMNs

A

EIEC

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17
Q

E. coli: Nonmotile and usually non lactose fermenting

18
Q

E. coli: Acute, prolonged (>7d), and persistent diarrhea (>14) in children less than 2

19
Q

E. coli: Outbreaks in daycare centers

20
Q

E. coli: Studies show that breastfeeding is protective against diarrhea caused by

21
Q

E. coli: Duodenum through colon

22
Q

E. coli: Colonization causes blunting of villi, inflammatory changes, and sloughing of superficial mucosal cells

23
Q

E. coli: Characteristic attaching and effacing histopathologic lesion

24
Q

E. coli: Abdominal pain with diarrhea that is initially watery but within a few days become blood-streaked or grossly bloody

25
Associated with HUS
STEC
26
Severe illness with STEC occurs in what age-group
6m-10yrs
27
STEC-positive young children with ___ early in the course of diarrhea are at high risk for HUS progression
Bloody diarrhea and neutrophilic leukocytosis
28
Poorly cooked hamburger, apple cider, mayonnaise, spinach, dry fermented sausage, unpasteurized dairy
STEC
29
STEC affects the ___ most severely
Colon
30
Attaching-effacing lesions like those seen in EPEC but with production of toxins that kill cells
STEC
31
Key virulence factors of STEC
Shiga toxins aka VEro toxins aka Shiga like toxins
32
The ___ family of toxins produced by STEC is associated with a higher risk of causing HUS
Stx2
33
MC STEC serotype
O157:H7, O111:NM and O26:H11
34
Most virulent STEC serotype
O157:H7
35
E coli most frequently associated with HUS
O157:H7
36
2nd MCC of traveler's diarrhea
EAEC
37
Acute and persistent diarrhea in HIV-infected adults and children
EAEC
38
Associated with growth retardation and malnutrition in infants
EAEC
39
Form a characteristic biofilm on the intestinal mucosa and induce shortening of the villi
EAEC
40
Secretory mucoid diarrhea
EAEC
41
AA fimbriae
EAEC