Chlamydial infections Flashcards
T/F Chlamydophila pneumoniae are obligate intracellular pathogens
T
Chlamydophila: Infectious form
Elementary body (EB)
Chlamydophila: Reproductive form
Reticulate body (RB)
T/F Ability to cause prolonged often subclinical infection is one of the major characteristics of chlamydiae
T
T/F Pneumonia caused by Chlamydophila is a classical atypical type with mild to moderate constitutional symptoms and CXR worse than clinical status of px
T
Optimum site for culture of C. pneumoniae
Posterior nasopharynx
Effective for eradication of C. pneumoinae from nasopharynx in ~80% of cases
Erythromycin, clarithromycin, azithromycin
Most important preventable cause of blindness in the world
Trachoma caused by chlamydia trachomatis
Criteria for trachoma
2 of 4: 1) Lymphoid follicles on upper tarsal conjunctivae 2) Typical conjunctival scarring 3) Vascular pannus 4) Limbal follicles
WHO recommends ___ for treatment of trachoma in children
Single-dose azithromycin
C. trachomatis is a major cause of what STDs
Epididymitis and nongonococcal urethritis
As many as ___% of men with gonorrhea may be co-infected with C. trachomatis
50
T/F Detection of C. trachomatis in vagina or rectum of a young child is an absolute evidence of sexual abuse
F, Perinatally acquired vaginal and rectal infection can persist for ≥3 years
Culture specimens for chlamydia detection
Urethral discharge in men and endocervical secretions in women
1st line treatment regimen recommended by CDC for uncomplicated C. trachomatis genital infection in men
Azith and Doxy
1st line treatment regimen recommended by CDC for uncomplicated C. trachomatis genital infection in nonpregnant women
Azith and Doxy
Sex partners of patients with NGU should be treated if
1) They have had sexual contact with patient during the 60 days preceding onset of symptoms 2) MOST RECENT sexual partner even if last sexual contact was >60 days from onset of symptoms
Approximately ___% of infants born to mothers with active untreated chlamydial infection develop clinical conjunctivitis
30-50
Characteristic presentation of C. trachomatis infection: Onset
Between 1- 3 mos of age
Characteristic presentation of C. trachomatis infection: Symptoms
Perisistent cough, tachypnea, ABSENCE OF FEVER
Characteristic presentation of C. trachomatis infection: Signs
Rales, wheezing uncommon
Helps to distinguish chlamydia pneumonia from RSV pneumonia
Absence of wheezing and fever
Characteristic presentation of C. trachomatis infection: Distinct labb finding
Peripheral eosinophilia (>400cells/mm3)
Characteristic presentation of C. trachomatis infection: Most consistent finding on chest radiograph
Hyperinflation, minimal interstitial or alveolar infiltrates
Recommended treatment regimen for C. trachomatis conjunctivitis in infants
Erythromycin
Recommended treatment regimen for C. trachomatis pneumonia in infants
Erythromycin
CDC-recommended treatment of C. trachomatis infection in pregnant women
Azithromycin or Amoxicillin
Lymphogranuloma venereum is a systemic STD caused by what organism
C. trachomatis
LGV strains of C. trachomatis have a predilection for
Lymphoid tissue
Stages of Lymphogranuloma Venereum
1st, Painless transient papules in the genitals (primary lesion; 2nd, UNILATERAL femoral or inguinal lymphadenitis with enlarging painful bbuboes; 3rd, genitoanorectal syndrome with rectovaginal fistulas, rectal strictures, and urethral destruction
Recommended treatment for LGV
Doxy
