NEISSERIA SPECIES and MORAXELLA CATARRHALIS Flashcards
acute pyogenic infection, primarily in urethra, endocervix, anal canal, pharynx and conjunctiva. gonorrhea -“flow of seed”- urethral discharge was mistaken for semen.
Neisseria gonorrhoeae
Neisseria gonorrhoeae -“Venereal Disease”
Sexually Transmitted Infection
3 Outer Membrane proteins of Neisseria Gonorrhoeae
Protein I (porB)
Protein II (Opa)
Protein III (Rmp)
An outer membrane proteins that is protective against inflammation.
Protein I (porB)
An outer membrane protein that is adherence to phagocytic cells and EC.
Protein II (Opa)
An outer membrane protein that is reduction modified protein- blocks host serum IgG.
Protein III (Rmp)
attachment to host tissues present in types T1 T2 T3,T4,T5 (avirulent) -no pili
Pili — Neisseria gonorrhoeae
protect against phagocytosis.
capsule — Neisseria gonorrhoeae
Most commonly acquired by sexual contact from asymptomatic carrier (primary reservoir)
Epidemiology — Neisseria gonorrhoeae
HPV, C. trachomatis, N. gonorrhoeae
Epidemiology — Neisseria gonorrhoeae
(males )- purulent discharge and dysuria and
cervicitis (female)
Urethritis - Clinical Infections of Neisseria gonorrhoeae
(auxotypes) AHU strains ( require arginine, hypoxanthine, uracil)
Asymptomatic men - Clinical Infections of Neisseria gonorrhoeae
PID, sterility, ectopic pregnancy and perihepatitis (Fitz-HughCurtis syndrome)
Clinical Infections - Neisseria gonorrhoeae
Conjunctivitis (Ophthalmia neonatorum)
Clinical Infections - Neisseria gonorrhoeae
“gonorrhoeae” means
flow of seed
Primary sources are oral secretion/ respiratory droplets (close contact).
Clinical Infections - Neisseria Meningitidis
Abrupt onset of frontal headache, stiff neck, fever.
Clinical Infections - Neisseria Meningitidis
Release of toxins in the blood that breakdown the walls of the blood vessels.
Meningococcemia - Clinical Infections of Neisseria Meningitidis
hemorrhaging of blood into skin & mucous membranes
Purpura(bruises) and Petechial rash(red spot) — clinical infections of Neisseria Meningitidis
“Purpura” means
bruises
“Petechial rash” means
red spot
Disseminated intravascular coagulation (DIC) (normal coagulation is disrupted and abnormal bleeding occurs), septic shock, hemorrhage of adrenal glands (Waterhouse-Friderichsen syndrome)
Meningococcemia - clinical infections of Neisseria Meningitidis
Attachment to respiratory epithelial cell.
virulence factor of Moraxella catarrhalis
Commensal of the upper respiratory tract.
epidemiology — Moraxella Catarrhalis
Localized infections (otitis media and sinusitis)
clinical infections — Moraxella catarrhalis
Lower respiratory tract infections
clinical infections — Moraxella catarrhalis
Systemic infections (endocarditis, meningitis, etc
clinical infections — Moraxella catarrhalis
Glucose positive (yellow); all other are negative (red)
Neisseria gonorrhoeae
Glucose and maltose positive (yellow); all
other are negative (red
Neisseria meningitidis
all tubes negative (red
Moraxella catarrhalis
small, tan, translucent and raised
colony morphology — N. gonorrhoeae
small, tan, may be mucoid and convex
colony morphology — N. meningitidis
Smooth, opaque, gray to white colony may be wept intact (hockey puck), 48-hr colony - Wagon wheel
colony morphology — M. catarrhalis
Positive to Superoxol test- 30% H2O2
N. gonorrhoeae
