ENTEROBACTERIACEAE Flashcards
aka “enterics” or “coliforms”
Enterobacteriaceae
most common cause of UTI in humans.
Uropathogenic E. coli (UPEC)
adherence to epithelial cells
Pili — Uropathogenic E. coli (UPEC)
inhibit immune effector cells
Cytolysins — Uropathogenic E. coli
chelate iron
Aerobactin — Uropathogenic E. coli (UPEC)
Also known “Montezuma’s revenge” or “turista”
Enterotoxigenic E. coli (ETEC)
Disease of Enterotoxigenic E. coli (ETEC)
Epidemic (infant) diarrhea and traveler’s diarrhea
Heat-labile (LT) and heat stable (ST) enterotoxins
Virulence factor — Enterotoxigenic E. coli (ETEC)
Fimbria
Virulence factor — Enterotoxigenic E. coli (ETEC)
Invades enterocytes causing Shigella like infection
Virulence factor — Enteroinvasive E. coli (EIEC)
Disease of Enteroinvasive E. coli (EIEC)
Dysentery and Bloody stools
Strains can be non-motile or non-lactose fermenter
Other Characteristics- Sereny test (+) — Enteroinvasive E. coli (EIEC)
Bundle-forming pilus for attachment to cells of the small bowel.
Virulence factor — Enteropathogenic E. coli (EPEC)
Infantile diarrhea (watery with mucus but no blood)
Disease — Enteropathogenic E. coli (EPEC)
Also known as Verotoxic E.coli (VTEC)
Enterohemorrhagic E. coli (EHEC)
Cytotoxin (Verotoxin I & II) similar to Shiga toxin
Virulence factor — Enterohemorrhagic E. coli (EHEC)
Serotype O157:H7 strain (STEC) (sorbitol-MAC and MUG negative)
Virulence factor — Enterohemorrhagic E. coli (EHEC)
Hemorrhagic colitis and hemolytic uremic syndrome
Disease — Enterohemorrhagic E. coli (EHEC)
Associated with UTI and diarrheal disease.
Diffusely adherent E.coli (DAEC)
Adhere to HEp2 in a aggregative “stacked-brick” pattern.
Enteroaggregative E.coli (EAEC)
Produces watery diarrhea
Enteroaggregative E.coli (EAEC)
Respiratory tract (pneumonia) ,wound, urinary tract, blood (septicemia) ,and CSF (Meningitis) infections.
Disease syndromes — Klebsiella (Friedlander’s bacilli) and Enterobacter
May be encapsulated and appears as mucoid colonies that tend to “string”
Klebsiella (Friedlander’s bacilli) and Enterobacter
Klebsiella is associated with?
plasmid-mediated ESBL’s
Nosocomial and opportunistic pathogens causing bacteremia, septicemia, urinary tract, respiratory tract (pneumonias) and wound infections.
Virulence factor — Serratia and Citrobacter
produces a red pigment (prodigiosin)
S. marcescens — Serratia and Citrobacter
produces Lipase, Gelatinase and DNase.
S. marcescens — Serratia and Citrobacter
ONPG Positive
Serratia and Citrobacter
Opportunistic causing bacteremia, septicemia, urinary tract, respiratory tract and wound infection.
Virulence factor — Proteus, Morganella and Providencia
Laboratory Diagnosis — Rapid urease producer
Proteus, Morganella and Providencia
Laboratory Diagnosis — Phenylalanine deaminase positive
Proteus, Morganella and Providencia
Laboratory Diagnosis — Proteus produces “Swarming motility” and has a “burnt chocolate odor”
Proteus, Morganella and Providencia