Neisseria Flashcards
neissera morphology
gram negative diplococci
“meningococcus”
neisseria meningitidis
“gonococcus”
neisseria gonorrhoeae
neisseria meningitidis transmission
person-to-person via respiratory droplets
often occur in crowded conditions
carrier state in nasopharynx lasts days to months
small % it goes to blood
incubation is 1 week
where does neisseria meningitidis multiply?
outside cell
is neisseria meningitidis encapsulated?
yes- but gonorrhea is not
capsule has antiphagocytic properties that contributes to virulence
neisseria meningitidis virulence factors
capsule
protease that splits IgA
pili/OMPs- colonization and affect colony morpholgy
LOS- no O side chains but still acts as endotoxin
sub saharan meningitis belt
largest burden of meningococcal meningitis in the world
mostly type A
neisseria meningitidis serotypes
there are many different types/ outbreaks can occur when people from different areas congregate and there is no immuno protection to the foriegn serotypes
neisseria meningitidis symptoms
high fever, signs of meningitis, patechiae followed by large ecchymosis
waterhouse friederichsen syndrome
uncommone meningiococemia causes adrenal failure, circulator collapse and shock, death
treatment of neisseria meningitidis
penicllin, 3rd generation of cephalosporin
neisseria meningitidis vaccine
conjugate vaccine used in Africa
neisseria meningitidis grows on both blood agar and chocolate agar
ok
in opposition to haemophilius
gonococcus serotypes
over 100
gonococcus infection
STI via direct genital contact
also: rectal and pharyngeal
gonococcus virulence factors
pili- establish infection w/in an hour and impair phagocytosis
reach sub-epithelial CT, causing inflammation and pus
gonococcus complications of disseminated disease
arthritis-dermatitis syndrome
tendosynovitis
chronic pelvic inflammatory disease in females
gonococcus diagnosis
stain w/ exudate and PMN
like thayer martin selective medium
cultures w/ oxidase positive, gram - diplococci
gonococcus- glucose fermentation only
meningitidis- glucose and maltose only
gonococcus treatment
drug resistance 3 types:
plasmid mediated penicillinase
plasmid mediated tetracyclin
choromsome mediated resistant- broad resistance
use 3rd gen cephlasporin and tetracyclin or azythromicin for chlamydia
gonococcus vaccine
no vaccine
