Necrosis Flashcards
1
Q
Stages of MI - histologically - first
A
- Wavy fibers, increased pink cells, loss of ATP, spilling of calcium, more clumped proteins
2
Q
Stages of MI - histologically - second
A
- loss of nuclei and contraction band necrosis
3
Q
Stages of MI - histologically - third - 2 days after injury
A
Infiltration of neutrophils and macrophag e
4
Q
Stages of MI - histologically - end
A
Collagen deposition
5
Q
Necrosis is always
A
pathological - result of irreversible cell injury
6
Q
Coagulation of cytoplasmic proteins results in
A
Eosinophilia
7
Q
coagulation of DNA
A
basophilia
8
Q
Myelin figures are
A
Disrupted and coagulated phospholipids
9
Q
Pyknosis is:
A
Nuclear shrinkage and basophilia
10
Q
Karyorrhexis is
A
Nuclear fragmentation
11
Q
Karyolysis is:
A
Fading of the nucleus
12
Q
In order which cardiac proteins peak after injury
A
- Myoglobin first
- Cardiac creatinine kinase
- Troponins (20 hours after onset)
13
Q
The tissue morphology of necrosis is dependent on:
A
- The concentration of active hydrolytic enzymes - coag vs liquefactive
- The etiology of the injury - caseous vs fibrinoid vs Fat necrosis
14
Q
Examples of coagulative necrosis
A
- MI, renal infarct (localized area of coag necrosis)
15
Q
Key features of coagulative necrosis
A
- preserved architecture
- Hypereosinophilia
- Loss of nuclei
- Delayed entry of neutrophils
