Necrosis

Question 1

Stages of MI - histologically - first

Answer 1

1. Wavy fibers, increased pink cells, loss of ATP, spilling of calcium, more clumped proteins

Question 2

Stages of MI - histologically - second

Answer 2

2. loss of nuclei and contraction band necrosis

Question 3

Stages of MI - histologically - third - 2 days after injury

Answer 3

Infiltration of neutrophils and macrophag e

Question 4

Stages of MI - histologically - end

Answer 4

Collagen deposition

Question 5

Necrosis is always

Answer 5

pathological - result of irreversible cell injury

Question 6

Coagulation of cytoplasmic proteins results in

Answer 6

Eosinophilia

Question 7

coagulation of DNA

Answer 7

basophilia

Question 8

Myelin figures are

Answer 8

Disrupted and coagulated phospholipids

Question 9

Pyknosis is:

Answer 9

Nuclear shrinkage and basophilia

Question 10

Karyorrhexis is

Answer 10

Nuclear fragmentation

Question 11

Karyolysis is:

Answer 11

Fading of the nucleus

Question 12

In order which cardiac proteins peak after injury

Answer 12

1. Myoglobin first
2. Cardiac creatinine kinase
3. Troponins (20 hours after onset)

Question 13

The tissue morphology of necrosis is dependent on:

Answer 13

1. The concentration of active hydrolytic enzymes - coag vs liquefactive
2. The etiology of the injury - caseous vs fibrinoid vs Fat necrosis

Question 14

Examples of coagulative necrosis

Answer 14

1. MI, renal infarct (localized area of coag necrosis)

Question 15

Key features of coagulative necrosis

Answer 15

1. preserved architecture
2. Hypereosinophilia
3. Loss of nuclei
4. Delayed entry of neutrophils

Question 16

Examples of liquefactive necrosis (rapid release of enzymes)

Answer 16

1. Infections

2. Hypoxic death of CNS

Question 17

Key features of liquefactive necrosis

Answer 17

1. Architectural destruction
2. Hypereosinophilia of remaining cells
3. loss of nuclei
   PUS -

Question 18

Example of caseous necrosis (cheeselike friable), granulomatous

Answer 18

TB

indigestible stimulus - mycobacterium

Question 19

Example of fibrinoid necrosis

Answer 19

Vasculitis

Immune mediated destruction of vessel walls

Question 20

Example of fat necrosis

Answer 20

acute pancreatitis with release of lipase

combine FA with Ca –> saponification

Question 21

FAT necrosis is not true

Answer 21

cellular necrosis

Question 22

Gangrenous necrosis -most similar to which type of necrosis if dry

Answer 22

Applied to a limb that has lost its blood supply -usually coagulative necrosis

Question 23

Gangrenous necrosis becomes similar to ….. necrosis when degradative enzymes are released by bacteria and neutrophils

Answer 23

Liquefactive