Nausea and Vomiting Drugs

Question 1

Anticholinergic agent (muscarinic receptor antagonist)
Transdermal patch

Answer 1

Scopolamine

Question 2

Histamine H1 antagonist
Acts at vestibular afferents within the brainstem
Prevents and treats motion sickness

Answer 2

Dimenhydrinate

Question 3

Serotonin (5-HT3) receptor antagonists

Used for chemo-induced nausea NOT for motion sickness

Answer 3

Ondansetron

Granisetron

Question 4

SE of 5-HT3 antagonists

Answer 4

Constipation, diarrhea

Headache, lightheadedness

Question 5

Dopamine 2 receptor antagonist

General purpose anti-emetic

Answer 5

Prochlorperazine

Question 6

SE of Prochlorperazine

Answer 6

Restlessness

Question 7

THC
Lipid soluable and absorbed after oral administration
MOA probably related to neuronal CB1 receptor activation

Answer 7

Dronabinol

Question 8

SE of Dronabinol

Answer 8

Tachycardia, palpitations, vasodilation/facial flushing, dysphoria, vertigo, dizziness, lack of concentration, depersonalization

Question 9

Glucocorticoid

Nausea in patients with cancer – suppresses prostaglandin production and tumor inflammation

Answer 9

Dexamethasone

Question 10

Substance P receptor antagonist

Used with other anti-emetics for acute and delayed nausea and vomiting assoc with chemo, post-operative

Answer 10

Aprepitant

Question 11

SE of Aprepitant

Answer 11

Fatigue, nausea, constipation, hiccups

Question 12

Dopamine 2 receptor antagonist

Used for diabetic gastroparesis, gastroesophageal reflux

Answer 12

Metoclopramide

Question 13

SE of Metclopramide

Answer 13

Tardive dyskinesia, dystonias