Natural History of Disease Flashcards
The natural history of disease is the ________ of a ________ process in an individual over ____, in the absence of ________
The progression of a disease process in an
individual over time, in the absence of treatment
T/F the time frame and specific manifestations of disease may vary from individual to individual and are influenced by preventive and therapeutic measures
T
What influences variation in time frame and specific manifestations of disease?
preventive and therapeutic measures
What happens in between susceptibility to disease and subclinical stage of disease?
Exposure
In which stage do pathologic changes occur?
Subclinical stage
What happens in between subclinical and clinical stage of disease?
onset of symptoms
Usual time of diagnosis is in which stage?
early stage of clnical disease
What are the 3 possible outcomes of disease?
recovery, disability, death
The disease process begins with the ________ to or
accumulation of factors __________ for the disease
process to begin in a ____________ ____
The disease process begins with the exposure to or
accumulation of factors sufficient for the disease
process to begin in a susceptible host
Which stage is a.k.a incubation/latency period?
stage of sublinical disease
T/F Disease is not apparent in the incubation period and cannot be detected by any screening methods
F Although disease is not apparent during the
incubation period, some pathologic changes may be
detectable with laboratory, radiographic or other
screening methods
Intervention is more effective when applied during which stage? Subclinical or Clinical?
Subclinical
In others, the disease process may result in illness that ranges from mild to severe or fatal. This range is called the
spectrum of disease
Refers to the proportion of exposed persons who
become infected; Measures the ability of an agent to invade and adapt itself to the human host
Infectivity
Refers to the proportion of infected individuals
who develop clinically apparent disease;
Measures the ability of an agent when lodged in
the body to set up a local or general tissue
reaction
Pathogenicity
