NASH Flashcards
1
Q
define
A
Non-alcholic stetohepatitis, there is inflammation and liver cell damage due to the deposition of fat in liver
- increases risk of MI, stroke and DM
2
Q
aetiology/risk factors
A
obesity T2DM hypertension over 50 smoking hypercholesteremia
3
Q
epidemology
A
most common liver disorder in developed world. 1/3rd of the UK
4
Q
symptoms
A
Usually asymp unexplained weight loss fatigue weakness Dull aching RUQ pain Cirrhosis in later stages
5
Q
signs
A
- RUQ abdominal discomfort
- Pruritis
- Jaundice
- Nail changes
- Palmar erythema
6
Q
investigations
A
Serum AST and ALT: Elevated
- Total bilirubin: elevated
- Alkaline phosphatase: elevated
- FBC: Anaemia or thromocytopenia
- Serum albumin: Decreased
7
Q
management
A
- Diet and exercise
- Weight loss pharmacotherapy
- With diabetes: insulin sensitiser
- With dyslipidaemia: lipid lowering therapy
8
Q
complications
A
- Ascites
- Variceal haemorrhage
- Portosysemic encephalopathy
- Hepatorenal syndrome
9
Q
prognosis
A
NASH associated with increased overall mortality, result of CVD and lesser extent liver-related causes
- Progress to cirrhosis 9-20 % of time
