Nasal tumours Flashcards
What are some benign tumours that can form in the nose?
Sinonasal papillomas (Squamous cell papilloma most common)
Angiofibromas
What are some risk factors of sinonasal papillomas?
HPV
Organic solvents
Who is most likely to get a sinonasal papilloma?
Males
Over 50
What are the 3 histological subtypes of sinonasal papilloma?
Inverted, exophytic or oncocytic
Where do inverted and oncocytic sinonasal papillomas form?
Lateral walls and paranasal sinuses
Where do exophytic sinonasal papillomas form?
Nasal septum
Describe the histology of sinonasal papillomas
- Epithelium can be respiratory, squamous, or oncocytic with mucocytes and neutrophilic infiltrate
- Rarely undergo malignant change
What condition causes formation of numerous papillomas?
Recurrent respiratory papillomatosis
What is recurrent respiratory papillomatosis?
Rare condition in which papilloma form along the aerodigestive tract
How can recurrent respiratory papillomatosis present?
Present in children with hoarse voice and progressive SOB
Associated with HPV
What are some malignant nasal tumours?
Nasopharyngeal carcinoma (SCC most common)
Primary adenocarcinoma
Neuroblastoma
Lymphoma
Where in the world has a high incidence of nasopharyngeal carcinoma?
Far East
What are some risk factors for nasopharyngeal carcinoma?
- Male
- EBV
- Volatile nitrosamines in food
- Occupation
- Family history
- Smoking and alcohol
- HPV
What are the 3 histological sub-types of nasopharyngeal carcinoma?
Keratinising SCC
Non-keratinising SCC
Baseloid SCC
Describe the spread of nasopharyngeal carcinomas
Highly malignant - extensive local spread, early nodal metastasis
