Narcotic Agonist-Antagonist

Question 1

Drug Names

Answer 1

Buprenorphine
Butorphanol
Nalbuphine
Pentazocine

Question 2

MOA-

Answer 2

Act at a specific opioid receptor sites in the CNS to produce analgesia, sedation, euphoria, and
hallucinations

Question 3

Indication

Answer 3

Moderate to severe pain
Adjunct to general anesthesia
Relief of pain during labor and delivery

Question 4

Contraindications

Answer 4

Known allergy

Nalbuphine- if sulfite allergy (cross allergy)

Question 5

Cautions

Answer 5

Physical dependence on a narcotic
COPD and disease of the respiratory tract (risk of respiratory depression)
Acute MI or documented CAD (exacerbate condition)
Renal or hepatic dysfunction (high risk for toxicity)
Pregnancy and lactation (affect neonate or fetus)

Question 6

Drug-Drug interactions

Answer 6

Barbiturate general anesthetics (high risk of life threatening ADE. Respiratory depression, hypotension, coma, death)
Narcotic agents (increased risk of respiratory depression)

Question 7

Adverse Effects

Answer 7

Respiratory depression (serious)
Nausea, vomiting, constipation, and biliary spasm actions
Headache, dizziness, psychoses, anxiety, hallucinations
Ureteral spasm, urinary retention
Sweating and dependence