Narcotic Agonist

Question 1

Drug Names - 6

Answer 1

Morphine
Hydromorphone
Codeine
Oxycodone
Fetanyl
Hydrocodone

Question 2

MOA

Answer 2

Act at specific opioid receptor sites in CNS

Produce analgesia, sedation, and sense of well-being (euphoria)

Question 3

Indications

Answer 3

Relief of severe acute or chronic pain
Analgesia during anesthesia
Labor

Question 4

Contraindications

Answer 4

Allergy

Diarrhea caused by poisons (ADE is usually constipation)

Question 5

Caution

Answer 5

◦ Respiratory dysfunction
◦ Pregnancy, labor, lactation
◦ GI or GU surgery
◦ Acute abdomen or ulcerative colitis
◦ Head injuries, alcoholism, delirium tremens, CVA (stroke due to CNS effect)
◦ Liver or renal dysfunction (risk of toxicity)

Question 6

Drug-to-Drug Interactions

Answer 6

Barbiturate general anesthetics
Phenothiazines (risk for respiratory depression)
MAOIs (increased risk for serotonin syndrome)

Question 7

Adverse Effects

Answer 7

Respiratory depression with apnea (most common)
Cardiac arrest
Shock
Orthostatic hypotension
Nausea, Vomiting,
Constipation
Dizziness