Narcotic Agonist

Question 1

Actions

Answer 1

• acts at specific opioid receptor sites in the CNS

- produces analgesia, sedation & a sense of well-being

Question 2

Uses

Answer 2

• relief of severe acute or chronic pain
• analgesia during anesthesia
• cross placenta

Question 3

Ex

Answer 3

• codeine
• fentanyl (Duragesic)
• meperidine (Demerol)
• methadone (Dolophine)
• morphine
• hydromorphone (Dilaudid)
• oxycodone (OxyContin)

Question 4

Pharmacokinetics

Answer 4

• IV is the most reliable way
• IM and sub-q rate of absorption varies
• hepatic metabolism and usually excreted in the urine & bile

Question 5

contraindications

Answer 5

• allergy
• pregnancy
• labor
• lactation
• diarrhea caused by poisons

Question 6

Cautions

Answer 6

respiratory dysfunction:

• GI or GU surgery
• acute abdomen or ulcerative colitis

adverse reactions:

• resp depression with apnea
• cardiac arrest
• shock
• orthostatic hypotension
• nausea
• vomiting
• constipation
• biliary spasm
• dizziness
• psychoses
• anxiety
• fear
• hallucinations

Question 7

Drug-drug interactions

Answer 7

• barbiturate general anaesthetics
• phenothiazines
• MAOIs