Nap attack 3

Question 1

essential amino acids

Answer 1

phillmttv phenylalanine, histidine, isoleucine, leusine, lysine, tryptophan, threonine, valine

Question 2

selenocysteine encoded by

Answer 2

UGA codon with the presence of a selenocysteine insertion sequence

Question 3

selenocysteine synthesized by

Answer 3

specialized tRNA’s, 54 proteins in humans that have it

Question 4

Pyrollysine

Answer 4

found in proteins of some methane producing archaea and bacterium
incorporated during translation
encoded by UAG (usually stop) , it’s synthesis and incorporation into protein is mediated via a pylTSBCD cluster

Question 5

fMET

Answer 5

initiating residue in the synthesis of bacterial proteins

• addition of formyl group catalyzed by methionyl tRNA formyltransferase after methionine loaded onto tRNA^fmet
• delivered to assembling ribosome by specialized tRNA^fMet with an anticodon that binds AUG

Question 6

Advantages of creating biomolecules as polymers of smaller simpler building blocks

Answer 6

1) Simplicity of chemistry - one reaction for polymerization, a second for degradation
2) Recycling - biomolecules digested back and used to make other biomolecules
3) vast number of molecules of varying lengths and sequences

Question 7

amphoteric

Answer 7

can act as weak acid and weak base

Question 8

triprotic amino acids

Answer 8

calthag(cowtag with three legs) lysine, arginine, histidine, aspartate, glutamate, cysteine, tyrosine

Question 9

zwitterion

Answer 9

dipolar ion of an amino acid

Question 10

influence of microenvironment on amino acid pka values

Answer 10

nearby negative charge makes pKa higher
nearby positive charge makes pKa lower
non-polar surrounding elevates the pKa of COOH but lowers that of NH+3

Question 11

Chirality

Answer 11

Describes the handedness of a molecule that is observable by the ability of a molecule to rotate the plane of polarized light to the left (leverotatory) or the right (Dextrorotatory

Question 12

virtually every cellular process regulated by

Answer 12

phosphorylation

Question 13

Understanding cellular kinase(kinome) activity can:

Answer 13

Offer insight into complex biology, indentify biomarkers, and provide therapeutic targets

Question 14

Design Array for Phosphorylation Experiments (DAPPLE)

Answer 14

automates identification of putative phosphorylation sites in an organism of interest, improving and accelerating design of kinome microarrays

Question 15

Platform for Integrated, Intelligent Kinome Analysis (PIIKA2)

Answer 15

enables customized analysis of kinomic data