Myeloproliferative Neoplasms

Question 1

CML arises from a single genetic translocation in a pluripotential HSC producing a clonal overproduction of the ____ cell line.

Answer 1

Myeloid

Question 2

Blast crisis involves the peripheral blood, ____, & ____.

Answer 2

Bone marrow; extramedullary tissues

Question 3

The point mutation in JAK2 replaces guanine with ____ at exon 14 of the gene, which changes the amino acid at position 617 from valine to phenylalanine.

Answer 3

Thymine

Question 4

What is the least common but most aggressive form of MPN?

Answer 4

Primary myelofibrosis