Acute Leukemias, Lymphoid & Plasma Cell Neoplasms, MPN Flashcards
Tumor suppressor gene cause cancers such as leukemia when mutations result in:
Failure to prevent malignant process
In what age group does acute lymphoblastic leukemia occur with the highest frequency?
1-15 years old
The WHO classification requires what percentage for the blast count in the blood or bone marrow for the diagnosis of AML?
At least 20%
In addition to morphology, cytochemistry, and immunophenotyping, the WHO classification of myelo- and lymphoproliferative disorders is based upon which characteristic?
Cytogenetic abnormalities
In the FAB classification, myelomonocytic leukemia would be?
M4
The M:E ratio in myelocytic leukemia is usually:
High
Chloromas are associated with:
High
What is the most common presentation of acute erythroid leukemia?
> 50% of nucleated marrow cells are erythroid precursors & >20% are myeloblasts
The M:E ratio in erythroleukemia is usually
Low
Auer rods are most commonly seen in what type of leukemia?
Promyelocytic leukemia
What cytochemical stain can be used to differentiate AML from ALL?
MPO
Naphthol AS-D chloroacetate esterase is usually positive in ____ cells, and alpha-naphthyl acetate esterase is useful for identifying blast cells of ____ lineage.
Granulocytic; monocytic
A peripheral smear shows 75% blasts. These stain positive for both Sudan Black B and peroxidase. Given these values, which of the following is the most likely leukemia diagnosis?
Acute myelocytic
What is the gene translocation in FAB M2?
t(8;21)
What is the gene translocation in FAB M3?
t(15;17)
What AML cytogenetic abnormality is associated with acute myelomonocytic leukemia with marrow eosinophilia under the WHO classification of AML with recurrent genetic abnormalities?
inv(16)
What leukemia is characterized by an increase in monoblasts and monocytes?
FAB M5
What is the WHO classification of FAB M7?
Acute myeloid leukemia not otherwise specified
Based on the WHO classification system, B cell ALL (FAB L3) and ____ represent different clinical presentations of the same disease identity.
Burkitt lymphoma
Terminal deoxyribonucleotidyl transferase is present in:
Precursor B and precursor T lymphoid cell
What is the translocation most commonly associated with Burkitt lymphoma?
t(18;14)
The (8;14) translocation brings which 2 genes in close proximitu?
c-myc and Ig heavy chain
What genetic alterations is associated with favorable diagnosis in pre-B ALL?
t(12;21)
Chronic lymphocytic leukemia is defined as:
An accumulation of B lymphocytes
