Anemias Flashcards
During inflammation, the liver increases the synthesis of ____ in response to IL-6.
Hepcidin
Iron-binding protein in the granules of neutrophils; has greater avidity for iron than transferrin; important intracellularly for phagocytes to prevent phagocytized bacteria from using intracellular iron for their metabolic processes
Lactoferrin
____ are the hallmark of sideroblastic anemias; presence of these show that the iron is awaiting incorporation into heme
Ringed sideroblasts
Accumulation of ____ or ____ & _____ are some of the results of lead interferences in porphyrin synthesis
Aminolevulinic acid; iron & protoporphyrin
Reticulocyte count in acute poisoning may be quite ____.
Elevated
____ and/or ____ are often used to chelate the lead present in the body so it can be excreted in the urine.
Calcium disodium edetate; dimercaprol
____ may develop as a result of mutations in genes for proteins controlling iron kinetics so that feedback regulation of iron is impaired.
Hemochromatosis
Defined as accumulation of 5-methyl THF acccumulates
Folate trap
In the plasma, only 10-30% of B12 is bound to transcoblamin; the remaining 75% is bound to transcobalamin I & III, referred to as ____.
Haptocorrins
Known as the loss of H+ production in the stomach
Achlorhydia
In stress hematopoiesis there is an increase in progenitor cell turnover, and the telomeres become ____ with each cell division.
Shorter
Triad of dyskeratosis congenita
Abnormal skin pigmentation
Dystrophic nails
Oral leukoplakia
The acquired form of pure red cell aplasia in young children is also known as:
Transient erythroblastopenia of childhood (TEC)
What are the 2 transmembrane proteins that provide vertical structural integrity to the cell by anchoring the lipid bilayer to the underlying spectrin cytoskeleton?
Akyrin complex & actin (protein 4.1) junctioning complex
2 major cytoskeletal proteins ____ & ____ interact laterally with each other to form antiparallel heterodimers.
a-spectrin; B-spectrin
