Myeloid Malignancy

Question 1

what is the pathology of AML

Answer 1

cells don’t differentiate

bone marrow failure of neutrophils etc

Question 2

what are the symptoms of AML

Answer 2

anemia 
infection
thrombocytopenia
prolonged infection
raised neutrophils

Question 3

what investigations for AML

Answer 3

blood count
bone marrow mostly blasts
lumbar puncture

Question 4

what are the treatments for AML

Answer 4

chemo

allogenic stem cell transplantation

Question 5

what is the pathology of CML

Answer 5

cell proliferate and differentiate

life long cells

Question 6

what are the symptoms of CML

Answer 6

anaemia
splenomelagy
weight loss
gout

Question 7

what investigations for CML

Answer 7

•	WCC-very high
•	Platelets high
•	Most WCC neutrophils 
•	Bone marrow hypercellular 
•	Philedelphia chromosome •	WCC-very high
•	Platelets high
•	Most WCC neutrophils 
•	Bone marrow hypercellular 
Philadelphia chromosome

Question 8

what is the treatment for CML

Answer 8

• Tyrosine kinase inhibitors:
• matinib-direct inhibitor
• dasatinib
• Nilotinib
• Busitinib
• Ponatinib