Lymphoid Malignancy Flashcards
what is leukaemia
cancer of white blood cells
what is lymphoma
cancers of lymphoid origin
can present enlarged lymph nodes
what are non Hodgkin diseases
acute lymphoblastic leukaemia
chronic lymphocytic leukaemia
non-hodgkin lymphoma
what is the pathology of ALL
cancerous disorder of lymphoid progenitor cells
no differentiation
rapid growth of immature cells
what are the symptoms of ALL
common in children limping child impaired vision anaemia weight loss
what are investigations for ALL
thrombocytopenia
bone marrow are lymphoblasts
PET scan
test for immature markers
what is the treatment for ALL
induction of chemo consolidation therapy methotrexate bi specific T cell engagers car T cells
what is the pathology of CLL
abnormal cells are mature
grow slowly
carry normal markers
what are the symptoms of CLL
bone marrow failure lymphadenopathy splenomegaly fever sweats asymptomatic
what inveisgtations would you do for CLL
haemolytic anaemia
staging
what is the treatment for CLL
incurable
watch and wait
cytotoxic chemo
monoclonal antibodies
what is high grade Hodgkins lymphoma
diffuse large B cell lymphoma
aggressive and fast growing
combination chemo
can be cured
what is low grade Hodgkins lymphoma
follicular lymphoma
asymptomatic
incurable
what is the symptoms of hodkings lymphoma
young adult
lymphadenopathy
drenching night sweats
lost weight
what are the investigations for Hodgkins
FBC_CRP raised
pet scan
what is the treatment for Hodgkins
combination chemo
radiotherapy
immunotherapy
