Myasthenia Gravis Médications

Question 1

What are the medication options for Myasthenia Gravis? (hint: Cooperative inmates)

Answer 1

1.cholinesterase inhibitors
2. Immunosuppressive drugs (e.g prednisone)

Question 2

What Cholinesterase inhibitors should you know?
(hint: “-stigmine”)

Answer 2

1. Neostigmine (nee-oh-STIG-meen)
2. Pyridostigmine (peer-id-oh-STIG-meen).

Question 3

What are the common uses of Cholinesterase inhibitors?

Answer 3

treating symptoms of myasthenia gravis and they also reverse certain nondepolarizing neuromuscular blocking agents after surgery.

Question 4

Cholinesterase inhibitors Mechanism of Action

Answer 4

Motor neurons release acetylcholine, causing skeletal muscle contraction. After acetylcholine is released, an enzyme called cholinesterase quickly breaks down the neurotransmitter. Cholinesterase inhibitors temporarily bind to cholinesterase, slowing it down. This causes levels of acetylcholine to increase, producing stronger muscle contractions.

Question 5

What are the Cholinesterase inhibitors high yield concepts?

Answer 5

1. difficulty swallowing
2. Dose adjustment
3. Acute toxicity

Question 6

Difficulty swallowing considerations

Answer 6

Assess a person’s swallowing ability by asking the client to take a few sips of water. If the client has difficulty, notify the provider and request a parenteral form be ordered.

Question 7

Signs of under-medication include

Answer 7

ptosis and difficulty swallowing.

Question 8

A key sign of overmedication is

Answer 8

Excessive salivation

Question 9

Acute toxicity of Cholinesterase inhibitors lead to _____

Answer 9

Cholinergic crisis

Question 10

Characteristics of Cholinergic crisis include

Answer 10

-Salivation
- Lacrimation (excessive tearing)
- Urination
- Diaphoresis/Diarrhea
- Gastrointestinal cramping
- Emesis
- Bradycardia, Bronchospasm, and Bronchorrhea (lots of watery sputum)

Question 11

Antidote for Cholinergic crisis

Answer 11

Atropine. After taking this, the patient should be medically ventilated