Myasthenia Gravis

Question 1

muscle fatigue and weakness from inadequate Ach receptor sight stimulation due to ACh receptor antibodies.

Answer 1

Myasthenia Gravis

Question 2

peak onset (Myasthenia Gravis)

Answer 2

10-65 yo 
Younger Woman(2x), Elderly = affected

Question 3

Diagnostics (Myasthenia Gravis)

Answer 3

Lab Test: Anti-Ach R: antibody present (85%)
Thymus abnormality (75%)
EMG (electromyography)
Tensilon Test (definitive for Dx)

Question 4

Tensilon Test

Answer 4

definitive for Dx for Myasthenia Gravis

Question 5

Muscles most affected by (Myasthenia Gravis)

Answer 5

bulbar (brainstem) and cranial nerves involvement–>eyes and eyelids (90%), chewing, swallowing, Facial muscles, expressions inhibited
–Distal muscles less affected

Question 6

Simpson eye test

Answer 6

indicative of Myasthenia Gravis

Question 7

Mestinon

Answer 7

1st Line→inhibits anticholinesterase (Myasthenia Gravis); Stop breakdown of ACH

Question 8

myasthenic crisis

Answer 8

insufficient medication (failure to take meds, inadequate dose)
Ptosis, Dyspnea, Dysarthria (slurred/slowed), Dysphagia
Treated: Anticholinesterase

Question 9

cholinergic crisis

Answer 9

excessive medication

Question 10

Atropine

Answer 10

antidote for tensilon, have available

Question 11

Primary feature (Myasthenia Gravis):

Answer 11

muscle fatigue, esp. during activity and @ end of day; Strength restored by rest

Question 12

Tx (Myasthenia Gravis):

Answer 12

Anticholinesterase drugs (Mestinon)
Corticosteroids (Prednisone)
Immunosuppressants
Thymectomy
Plasmapheresis
Immunoglobulin G