Myasthenia Gravid Flashcards
What is myasthenia gravis?
A neuromuscular disorder characterized by weakness and rapid fatigue of voluntary muscles.
True or False: Myasthenia gravis is an autoimmune disease.
True
Which neurotransmitter is primarily affected in myasthenia gravis?
Acetylcholine
What is the main goal of pharmacological treatment in myasthenia gravis?
To improve muscle strength and reduce fatigue.
Fill in the blank: The first-line treatment for myasthenia gravis is __________.
Acetylcholinesterase inhibitors
Name a common acetylcholinesterase inhibitor used in myasthenia gravis.
Pyridostigmine
What is the mechanism of action of acetylcholinesterase inhibitors?
They increase the availability of acetylcholine at the neuromuscular junction.
True or False: Corticosteroids are often used as a second-line treatment for myasthenia gravis.
True
What is the role of immunosuppressants in the treatment of myasthenia gravis?
To reduce the autoimmune response and improve muscle strength.
Which immunosuppressant is commonly used in myasthenia gravis treatment?
Azathioprine
What is the purpose of plasmapheresis in myasthenia gravis?
To remove antibodies from the blood.
Fill in the blank: __________ is a monoclonal antibody that targets the immune response in myasthenia gravis.
Rituximab
What is a potential side effect of acetylcholinesterase inhibitors?
Cholinergic crisis, characterized by excessive muscle stimulation.
True or False: Thymectomy is a surgical option for treating myasthenia gravis.
True
What is the benefit of thymectomy in myasthenia gravis?
It may reduce symptoms and the need for medication.
Fill in the blank: Myasthenia gravis is often associated with __________ gland abnormalities.
Thymus
What is the function of the thymus gland in relation to myasthenia gravis?
It plays a role in the immune system and may contribute to the production of antibodies.
Which type of myasthenia gravis is characterized by the presence of antibodies against the acetylcholine receptor?
AChR-positive myasthenia gravis
What is the significance of muscle-specific kinase (MuSK) antibodies in myasthenia gravis?
They indicate a subtype of myasthenia gravis that may require different treatment approaches.
True or False: Myasthenia gravis can lead to respiratory failure in severe cases.
True
What is a myasthenic crisis?
A severe exacerbation of muscle weakness leading to respiratory failure.
Fill in the blank: The treatment of a myasthenic crisis often requires __________.
Intensive care and possible ventilation support
Which medication can exacerbate symptoms of myasthenia gravis?
Aminoglycoside antibiotics
What is the primary pharmacological treatment for a myasthenic crisis?
Plasmapheresis or intravenous immunoglobulin (IVIG)
True or False: Lifestyle changes have no impact on managing myasthenia gravis symptoms.
False
