Anticholine Esterase

Question 1

Reversible(carbamates)

Answer 1

Physo(tertiary calabar beans) - convulsions collapse and coma and centres (CCCC)
Neo(quaternary synthetic)
Both twitch eyelid face and trunk
Neostigmine substitutes

Question 2

Irreversible(by phosphorylation of esteratic site) - pass bbb except
First loose then age

Answer 2

Di isopropyl flurophosphate
Metro and Echo(can’t bbb)thiophate
Sarin soman tabum
Para and malathion
-give diarrhea and cramps
-paralysis in over muscarinic

Question 3

Is pilocarpine a substrate for esterases
Does it have nicotinic myemsh?

Answer 3

Noi
But it passes bbb

Question 4

Rivastigmine

Answer 4

Alzheimers anticholine esterase

Question 5

DFP

Answer 5

Glaucoma

Question 6

Ecothiophate

Answer 6

Tried myasthenia gravis plus glaucoma

Question 7

Metrithiophate

Answer 7

Oral anti bilarzial

Question 8

War gases

Answer 8

Sarin and the rest

Question 9

Para and mala

Answer 9

Insecticide

Question 10

Over inhibition of RC and Vasomotor centres in organophosphorus intake

Answer 10

Leads to death

Question 11

Diagnosis f over organophosphorus

Answer 11

Decreased pseudo choline esterase levels(as is measurable in plasma)
History
Manifestations toxicity

Question 12

Comatose or vomiting

Answer 12

Lateral head down

Question 13

Endotracheal intubation

Answer 13

Unconcious

Question 14

Gastric lavage

Answer 14

After 1 to 2 hrs

Question 15

Activated charcoal

Answer 15

Absorbs OP

Question 16

Treatment of organophosphorus toxicity

Answer 16

Atropine
Oximes - paralidoxime and obidoxime plus diacetylmonooxime(DAM)
Benzodiazepines for seizure from poison or over atropine