Myasthe Grav, Myositis, Mm Dys, Acq, My, Mm Inj

Question 1

Mya G
Mechanism

Demo

Etio

Clinic Man

Prog

Answer 1

Autoimme atibod to Ach, Women 3:2

Age 20-35, Men 50-60

Unknown cause, 75% thymus hypla

Prox Mm UE first affect, death respiratory Mm par

Thmectomy, 40% mortality w/i 5 yrs

Question 2

4 Forms of Immune Myo

Answer 2

Poly - Chron inflam Mm
Dermatomyo - Other org, skin

Myositis SLE - Abn. immun complx in blood vessels to Mm

Saarcoidosis - granuloma form

Question 3

Immune Myo Tx

Answer 3

Cortico st. + immunosupp

Question 4

Sarcoidosis

Answer 4

Multiinflam - Pulmon, lymph, skin, eyes, less the Mm sys.

Question 5

Duchenne’s Mm Dys
S+S

Demo

Beckers is _____ more/less cmn

Answer 5

Most Cmn Mm dys.

Mm weakness on weight carrying of Pelvic girdle + LE, diff squat

In boys

10x less common

Question 6

Duchenne early gait
Wheelchair at

Main cause of death at age

Answer 6

Waddling
10-12

Respir insufficency early teens/20s

Question 7

Myotonic Dys

Answer 7

“hatchet face”, systemic (diabete, frontal bald)

Male: female

Muscles cannot relax immediately

Question 8

Acq Myopath

Answer 8

Diabete, thyroid, autoimmune

Question 9

Diabete Myo 3 cause

Answer 9

Vascular (hypoperfusion) , neurogenic, (peripheral N.)

Metabolic - glucose entry to Mm c.

Question 10

Other ac q. myopath

Answer 10

Hormonal: hyperthyoid (incr. meta
Hypothyoid (sluggish energy)

Autoimmune (RA), 2ndry to rheumatic jt disease

Question 11

Cancer Myopathy

Answer 11

Cmn paraneoplastic synd

Tumor antibodies -> inflammation (Dermatomyositis)

Question 12

Rhabdomyolysis

Etiology

Progn -

Answer 12

Creatine physphokinase release due to injury

Renal fail

High dose statin tx, strenous/exertional rhabdomyolysis, hot temp/dehy

Can resolve w/o conseq