MW L1 The Inflammatory Process Flashcards
Infection is
‘catching and spreading’
involves microbes colonising a host
Immunity is
‘protection from infection or disease’
-but includes autoimmunity
Inflammation is
‘set alight’
part of immunity and stimulated by infection and other injury
What is the point of the inflammatory process?
Attack and remove cause of injury, repair damaged tissue
beneficial and self protecting
5 factors of inflammation
- heat
- redness
- swelling
- pain
- loss of funciton
What neurones modulate nociception?
Sensory neurones
Sensory neurones release neuropeptides such as ………… and …………… which contribute to redness and swelling
Substance p
Calcitonin
Mast cells release (2)
histamine and PGs
Inflam involves interplay between…. (5)
- microvasculature
- leukocytes
- nerves
- tissue cells (structural & immune)
- chemical mediators of inflammation
RA affects ……… of the population
age of onset?
1-2%
30-50
RA affects what ration of women to men
3 women : 1 man
RA has complex pathology involving what factors: (5)
genetic immunological hormonal neuronal environmental
Why does RA remis in pregnancy?
hormonal changes
Loss of cartilage, bone erosion in RA is mediated by….
MMP
Matrix MetaloProteinases
MMP are secreted by….
synovial fibroblasts
chondrocytes