JAL L5 Inhibitors of cell wall synthesis

Question 1

2 e.g. of glycopeptides

Answer 1

vancomycin, teicoplanin

Question 2

glycopeptides are active against gram….

Answer 2

positive only

Question 3

Do glycopeptides have problems with resistance?

Answer 3

Yes

Question 4

first line treatment for MRSA?

Answer 4

Vacomycin

Question 5

Vanc is used orally for….

Answer 5

C. diff (I.V. otherwise)

Question 6

Teicoplanin administered by …..

Answer 6

IV or IM

Question 7

PK of glycopeptides

Answer 7

penetrate the CSF

Excreted by the kidney

Question 8

s/e glycopeptides

Answer 8

pain and thrombophlebitis at injection site
renal tox
ototoxic
blood disorders
anaphylactoid reactions

Question 9

Cycloserine is effective against what terrible disease?

Answer 9

TB

Question 10

s/e Cycloserine

Answer 10

CNS, rashes, liver damage

Question 11

Cycloserine is broad or narrow spec

Answer 11

broad

Question 12

Bacitracin is combined with …… for skin & eye infections & prevent wound infection

Answer 12

polymyxin

Question 13

s/e bactiracin

Answer 13

contact allergic dermatitis

Question 14

Polymyxins work by…

Answer 14

disrupting the membrane —> leakage

Question 15

Polymyxins s/e

Answer 15

nephro and neurotoxic

locall irritation

Question 16

Polymyxins uses

Answer 16

resistant systemic infection

Question 17

Polymyxin are effective against gram …

Answer 17

-ve

Question 18

Lipopeptides e.g.

Answer 18

daptomycin

Question 19

daptomycin works by…

Answer 19

rapid depolarisation of the cytoplasmic membrane - loss of function

Question 20

daptomycin against gram

Answer 20

+ve

Question 21

daptomycin s/e

Answer 21

nephrotoxic, myopathy, peripheral neuropathy, colitis