JAL L4 β-Lactams Flashcards
R group of penicillins determines…. (5)
Selectivity (small enough to reach g-ve through porins)
Solubility (Na+ and K+ salts more soluble)
Stability (degrades in stomach pH?)
Bioavailability
β-Lactamase resistance
e.g. of β-Lactamase sensitive? (2)
Pen G
Penicillin V
e.g. of β-Lactamase resistant? (2)
Flucloxacillin: co-fluampicil
&
Temocillin (also resistant to G-ves)
e.g. of broad spectrum (2)
amoxicillin
ampicillin
e.g. of antipseudomonal (2)
piperacillin + tazobactam: Tazocin
Pen G is also called
benzylpenicillin
Pen G is orally active?
No
Does pen G have good distribution?
Yes into tissues and fluids, not into CSF (unless meningitis)
Pen G lasts for a long time?
Rapid excretion into the urine but long post antibiotic effect
To maintain Pen G levels we might:
- give larger doses
- frequent dosing
- combine with slow IM (benzathine benzylpenicillin)
Uses of Pen G (6)
Throat infections Meningitis Pneumonia Cellulitis Osteomyelitis Endocarditis (high dose! therefore not toxic!)
If meningitis suspected use………………. immediately
Pen G
3 Causes of meningitis:
LEARN LEARN LEARN.
Neisseria meningitidis
Strep. pneumoniae
Haemophilus influenzae
Ampicillin is oral because….
stable under acid conditions.
PK of ampicillin….
=40% absorption
Good CSF levels in meningitis but usually IM or IV.
Is there resistance to ampicillin
Yes
40% E.coli
Most staphylcocci