JAL L4 β-Lactams Flashcards

1
Q

R group of penicillins determines…. (5)

A

Selectivity (small enough to reach g-ve through porins)
Solubility (Na+ and K+ salts more soluble)
Stability (degrades in stomach pH?)
Bioavailability
β-Lactamase resistance

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2
Q

e.g. of β-Lactamase sensitive? (2)

A

Pen G

Penicillin V

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3
Q

e.g. of β-Lactamase resistant? (2)

A

Flucloxacillin: co-fluampicil
&
Temocillin (also resistant to G-ves)

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4
Q

e.g. of broad spectrum (2)

A

amoxicillin

ampicillin

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5
Q

e.g. of antipseudomonal (2)

A

piperacillin + tazobactam: Tazocin

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6
Q

Pen G is also called

A

benzylpenicillin

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7
Q

Pen G is orally active?

A

No

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8
Q

Does pen G have good distribution?

A

Yes into tissues and fluids, not into CSF (unless meningitis)

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9
Q

Pen G lasts for a long time?

A

Rapid excretion into the urine but long post antibiotic effect

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10
Q

To maintain Pen G levels we might:

A
  • give larger doses
  • frequent dosing
  • combine with slow IM (benzathine benzylpenicillin)
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11
Q

Uses of Pen G (6)

A
Throat infections
Meningitis
Pneumonia
Cellulitis
Osteomyelitis
Endocarditis (high dose! therefore not toxic!)
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12
Q

If meningitis suspected use………………. immediately

A

Pen G

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13
Q

3 Causes of meningitis:

A

LEARN LEARN LEARN.
Neisseria meningitidis
Strep. pneumoniae
Haemophilus influenzae

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14
Q

Ampicillin is oral because….

A

stable under acid conditions.

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15
Q

PK of ampicillin….

A

=40% absorption

Good CSF levels in meningitis but usually IM or IV.

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16
Q

Is there resistance to ampicillin

A

Yes
40% E.coli
Most staphylcocci

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17
Q

What is ampicillin used to treat? (4)

A

Throat
Dental
Resp
UTI etc.

18
Q

S/e of penicillins (4)

A
HYPERSENSITIVITY
1-10% rash
0.05% anaphylaxis
-----
neurotoxicity
renal failure
oral can cause diarrhoea
19
Q

How does superinfection occur?

A

Oral broad spectrum antibiotics kill gut bacteria, resistant bacteria cause superinfection.
>diarrhoea
> C. diff

20
Q

Cephalosporins are resistant to β-Lactamases?

A

Yes, not ESBLs

21
Q

Cephalosporins are active against gram +/-ve?

A

originally +ve

now also -ve

22
Q

Cephalosporins treat:

A

similar to penicillins

23
Q

PK of cephalosporins?

A

Mostly IM or IV, some oral.
Low penetration CSF (except meningitis)
Renal excretion.

24
Q

Cephalosporins cause hypersensitivity in what % of penicillin allergic patients?

A

0.5-6%

25
Q

S/e Cephalosporins

A

Diarrhoea, nausea, C. diff.

26
Q

1st generation Cephalosporins such as ……….. have generally been replaced and are active against gram …

A

cefazolin, cefradine

MOST gram +ve

27
Q

2nd gen Cephalosporins such as ………… have increased resistance to β-Lactamases

A

cefaclor

and increase gram -ve spectrum

28
Q

2nd generation are used for…

A

severe infection & preventing infection after surgery

29
Q

3rd generation cephalosporins such as ….. are used for….

A

ceftriaxone

Everything: CAP, hospital acquired infections etc.

30
Q

Subset of 3rd generation such as ceftazidime are active against….

A

p. aeruginosa

31
Q

4th generation cephalosporins are used for (2)

A

severe infections and p. aeruginosa

32
Q

4th generation cephalosporins have broader spectrum but,…

A

more resistance to β-Lactamases

33
Q

Carbapenems work by….

A

inhibiting cell wall synthesis

34
Q

Carbapenems are resistant or not to β-Lactamases

A

Very resistant

35
Q

Carbapenems have broad or narrow spectrum?

A

Broad. Including Ps. aeruginosa (but not against MRSA)

36
Q

Carbapenems used for (5)

A
Use IV for:
septicaemia
HA pneumonia
Intra-abdominal infections
complicated UTI
skin and soft tissue infections
37
Q

Monobactams work by….

A

inhibiting cell wall synthesis

38
Q

Monobactams have broad or narrow spectrum?

A

Narrow - only gram -ve aerobes

39
Q

Monobactams are resistant or not to β-Lactamases?

A

Resistant

40
Q

Monobactams are used for…

A

septicemia and complicated UTI

41
Q

Monobactams cause penicillin allergy?

A

No, less likely