JAL L5 Inhibitors of nucleic acid synthesis

Question 1

Sulfonamides inhibits what enzyme?

Answer 1

dihydropteroate synthetase

Question 2

Trimethoprim inhibits what enzyme

Answer 2

dihydrofolate reductase

Question 3

Why are trimethoprim and sulfonamides top?

Answer 3

because we don’t have the enzymes they inhibit ourselves

Question 4

Uses of sulfonamides

Answer 4

limited

Question 5

Trimethprim is active against gram…

Answer 5

-ve

Question 6

Trimethoprim is used in combination as

Answer 6

Co-trimoxazole

Question 7

s/e trimethprim

Answer 7

allergy, GIT, mylonosupression

Question 8

Co-trimoxazole s/e

Answer 8

more severe
liver damage
bone marrow suppression
Steven johnson sydrome

Question 9

Fluoroquinolones work by…

Answer 9

inhibiting DNA gyrase and type IV topoisomerase

Question 10

Fluoroquinolones are broad or narrow spec?

against gram….?

Answer 10

Broad

both

Question 11

Fluoroquinolones are cidal or static?

Answer 11

cidal

Question 12

Ciprofloxacin absorption is reduced by…

Answer 12

cations

Question 13

Main use of ciprofloxacin?

Answer 13

UTI

Question 14

ciprofloxacin s/e

Answer 14

GIT (c. diff)
CNS
cartilage dev
tendon damage
rash/ photosensitivity
renal impairment

Question 15

Rifamycins are static or cidal?

Answer 15

cidal

Question 16

Rifamycins are used against waht bid horrible disease?

Answer 16

TB

prophylaxis of meningitis

Question 17

Rifamycins PK

Answer 17

given orally, well distributed. Excreted: bile

Question 18

s/eRifamycins

Answer 18

hepatotoxicity
increase metabolism of other drugs
fever
rash
GIT
orangge secretions

Question 19

metronidazole works

Answer 19

by chopping up DNA

Question 20

PK of metronidazole

Answer 20

orally
well ditributed including CSF
metabolised in the liver
excreted in the urine

Question 21

s/e metronidazole

Answer 21

nausea, vomiting, constipation
CNS
hypersensitivity
red urine
candida superinfection