Mutation Flashcards
Structural mutations
Deletion, insertion, duplication, inversion, reciprocal translocation, fusion, fission, chromosomal duplication, whole genome duplication
Linkage disequilibrium
When an allele at one locus is found together in a population more often than expected by chance with an allele at a second locus
Can be produced by natural selection (epistasis)
Mutation rate
Probability that offspring carries a mutation
Epistasis
A situation in which the effect of an allele at one locus depends on the allele at a second locus
Combination leads to higher fitness
Pleiotropy
A single mutation affects multiple traits
Two effects of mutation
Pleiotropy
Effects on fitness
High mutation rates
In populations with low genetic variation
Asexual species
Selection coefficient
Effect mutation has on survival
-most mutations
Eg: SC= -0.1 —> decreases survival by 10%
Are mutations random
Transition mutations are more likely than transversions
-not all mutations equally likely
Mutations are random with respect to what will increase fitness
Maternal effect
When the genotype or phenotype of the mother directly influences the phenotype of her offspring