Musculoskeletal Flashcards

1
Q

What is carpel tunnel syndrome?

A
  • the medial nerve is compressed at the wrist
  • commonly affects women
  • can be caused by forceful and repetitive work
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2
Q

What tests can you use for diagnosis of carpel tunnel?

A
  • Tinel’s
  • Phalen’s
  • both will give a positive result
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3
Q

What is tenosynovitis?

A
  • Caused by inflammation of APL and EPB tendon-sheath

- Diagnosis via Finkelstein’s test

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4
Q

What is the treatment for tenosynovitis?

A
  • NSAIDS
  • Steroid injection
  • Rest
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5
Q

How do you diagnose an inflamed joint?

A
  • Blood culture
  • then aspirate the joint
  • if infected, it is cloudy and thicker than water
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6
Q

How would you manage an inflamed joint?

A
  • DMARD and anti-TNF injections
  • IV flucloxacillin
  • Prednisolone
  • Analgesia
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7
Q

What is septic arthritis?

A
  • painful infection in the joint

- Common organisms include staph aureus, streptococci, gonorrhoea, gram -ve bacilli

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8
Q

What is gonococcal arthritis?

A
  • Septic joint, in those with gonorrhea

- Disseminated gonococcal infection

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9
Q

What are the symptoms of gonococcal arthritis?

A
  • fever
  • tenosynovitis
  • pustular rash (common in palms and soles). Painful before visible
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10
Q

What are risk factors for a septic joint?

A
  • Any cause for bacteraemia
  • Direct trauma
  • Skin breaks/ulcers
  • Damaged joints
  • RA/ diabetes / elderly / immunosuppressed
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11
Q

What is the clinical presentation of a septic joint?

A
  • Painful, red, swollen, hot
  • fever
  • 90% monoarthritis (asymmetrical)
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12
Q

What is the management for a septic joint?

A
  • Aspiration
  • Antibiotics
  • Joint washout
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13
Q

What are the inflammatory markers used?

A
  • Single CRP (>10) and ESR (>30) = if raised, 50% chance of infection
  • Multiple CRP and ESR = if raised, 80% chance of infection
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14
Q

What is osteomyelitis?

A
  • Bone marrow inflammation, where the infection is localised to the bone
  • Severe, which needs to be recognised as early as possible
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15
Q

What are host factors for risk of osteomyelitis?

A
  • Behavioural e.g. risk of trauma
  • Vascular supply = DM or sickle-cell
  • Pre-existing bone/joint problem
  • Immune deficiency
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16
Q

What bacteria is mainly in osteomyelitis?

A
  • Staph aureus
  • C -ve staph
  • aerobic gram-ve bacilli
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17
Q

What are the signs and symptoms of osteomyelitis?

A
  • onset = several days
  • dull pain at site
  • systemic infection
  • Acute OM = tenderness and swelling
  • Chronic = draining sinus tract and large ulcers failing to heal
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18
Q

What can osteomyelitis of the joint also present as?

A
  • Septic arthritis

- when infection breaks through cortex resulting in discharge of pus into the joint (knee, hip, and shoulder).

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19
Q

What investigations can you do for osteomyelitis?

A
  • Lab tests = high WCC in acute OM. Raised inflammatory markers
  • Imaging - Xray or MRI
20
Q

What is the differential diagnosis of osteomyelitis?

A
  • Soft tissue infection
  • Avascular necrosis
  • Gout
21
Q

What is the treatment for osteomyelitis?

A
  • Surgical (debridement or removal)

- Antimicrobial therapy

22
Q

What are the red flag signs for soft bone tumours?

A
  • Pain at rest and in the night
  • Lump present - tender and deep to fascia
  • Loss of function
  • Unwell / weight loss
23
Q

What are the investigations for bone tumours?

A
  • Blood tests
  • X-ray
  • CT scan = bone quality
  • MRI scan = changes in soft tissue
24
Q

What is osteosarcoma?

A
  • Cell neoplasms that produce osteoid
  • Secondary includes Paget’s
  • Most common type
  • location: knee, proximal humerus or femur
25
What is the management of osteosarcoma?
- If left untreated, will be fatal - Chemotherapy pre-op - Limb salvage surgery as well as chemotherapy
26
What is intramembranous bone growth?
- Bone develops directly from sheets of mesenchymal connective tissue
27
What is endochondrial bone growth?
- Bone develops by replacing hyaline cartilage
28
What is crystal arthropathy?
- Arthritis caused by crystal deposition in joint lining | - Most common is urate = gout
29
How do crystal arthropathies present?
- Intense pain | - Acute with hot, swollen joints
30
What is gout?
- MSU crystals deposited in joint - Can be acute or chronic - Common in men 40+
31
Why is purine related to gout?
- Purine is in red meat and additives in fizzy drinks - When metabolised, some is excreted into renal or intestine - Get hypouricemic
32
What is hyperuricaemia?
- Excessive uric acid in the blood | - Major risk factor for gout
33
What can precipitate an attack of gout?
- Anything that causes sudden alteration in uric acid concentration - Alcohol/ shellfish binges - Sepsis, MI, acute illness - Trauma, surgery
34
What is the treatment for gout?
- anti-inflammatories - NSAIDS, colchicine, steroids - Xanthine oxidase inhibitors = allopurinol
35
What is pseudogout?
- Deposition of calcium pyrophosphate crystals on joint surface - These elicit an acute inflammatory response - Generaly MCPs, wrists, knees
36
What are the features of pseudogout?
- Acute synovitis - Severe pain, stiffness, swelling fever - resolved in 1-3 weeks - has pattern of involvement
37
What is osteoporosis?
- Skeletal disease with low bone mass and deterioration of bone tissue - Susceptible to fractures
38
What is post-menopausal osteoporosis?
- Loss of effects of oestrogen on bone turnover | - Preventable by oestrogen replacement
39
How do you diagnose osteoporosis?
- Bone densitometry - X-ray - DXA - T-score
40
What is osteopenia?
- Bones are weaker than normal, but do not have osteoporosis
41
What can increase your risk of osteoporosis?
- Inflammatory diseases e.g. RA and IBD - Endocrine diseases - Reduced skeletal loading - Medication e.g. glucocorticoids
42
What is a FRAX score?
- determines risk of injury or fracture
43
What is the treatment for osteoporosis?
- Anti-resorptive = biphosphonates (1st) and HRT | - Anabolic = teriparatide
44
What are the pros and cons for hormone replacement therapy for osteoporosis
- Pros = reduces risk of fractures by 50% - Stop bone loss - prevents hot flushes and menopausal symptoms - Risks include breast cancer, stroke, CVD
45
What are examples of biphosphonates?
- Oral = aledronate or risedronate | - IV = ibandronate
46
What is denosumab?
- Rapid acting and potent anti-resorptive - Good fracture risk reduction - rebound increase of bone turnover when stopped