Muscular System Flashcards
Muscular System
- system of the human body that provides motor power for all movements of the body
- composed for specialized cells: myocytes or muscle fibers
- CYTE = cell
- MYO = muscle
- more than 700 muscles in the body
- 639 known muscles with names
Functions of Muscular System
- Movement of the body
- Maintenance of Posture
- Respiration
- Production of Body Heat
- Communication
- Constriction of Organs and Vessels
- Contraction of the Heart
Respiration
- allows expansion of lung
- through the diaphragm (inhalation: depresses down)
Production of Body Heat
- shivering (interaction of muscles)
- any type of movement would
produce heat
Communication
verbal and non-verbal communication
Contraction of the Heart
muscle (hardest working muscle)
Skeletal Muscle
- constitutes approx. 40% of body weight
- attached to skeletal muscle
- voluntary: needs stimulus from CNS
- striated
- controlled by somatic nervous system
Cardiac Muscle
- location: HEART only
- involuntary
- striated
- controlled by
autonomic nervous system
Smooth Muscle
- constricts
- found on visceral hollow organs
(stomach, trachea,
urinary bladder) - involuntary
- not striated
Contractility
- muscle’s ability to shorten forcefully
- contraction
Excitability
muscle’s ability to respond to stimulus
Extensibility
stretch beyond / extend muscle from normal resting stage and still be able to contract
Elasticity
muscle’s ability to recoil to its original length after being stretched
Tendon
- attachment between muscles and bone matrix
- protein fibers of the three layers merge at the ends of most muscles
Epimysium
- connective tissue
surrounding entire
muscle - EPI: above
Perimysium
- connective tissue around muscle fascicles
- FASCICLES: muscle
fibers
Endomysium
- connective tissue
around muscle cells - ENDO: outside
Skeletal Muscle Fiber Anatomy
- unique cells with several nuclei
- under the cell membrane
- LENGTH: ranges from 1 mm - 4 cm
- increases in size
- can vary in length depending on body positions
- alternating light and dark bands = gives striated or striped appearance
Sarcolemma
cell memberane of muscle fibers
Transverse tubules
- t tubules
- tube-like fold of sarcolemma
- carries electrical impulses to center of muscle fibers so that it contracts as a whole
Sarcoplasmic Reticulum
- highly specialized
endoplasmic reticulum - stores high level of Calcium
Terminal Cisterna
enlarged portion = formation of Terminal cisterna forms triads
Myofibrils
- thread-like structures
- extend the entire length of muscle fibers
Myofilaments
- arranged into highly ordered units = sarcomeres
Actin Myofilament
- thin myofilaments
- proteins: actin, troponin, tropomyosin
- pearl-like structures
- relationship among Troponin and Tropomyosin = determines when skeletal muscle will contract
Tropomyosin
- long fibrous proteins
- lies in the groove along the fibrous actin strand
- covers attachment site
during muscle relaxation
Troponin
- anchors troponin to actin
- prevents tropomyosin from uncovering attachment site during muscle relaxation
- binds Calcium
Attachment Site
- if Calcium is not present = muscle relaxation = tropomyosin covers attachment site
- Calcium present = muscle contraction = attachment site = binds troponin
Myosin Myofilament
- thick filament
- composed of many elongated myosin molecules shaped like
golf clubs - MYOSIN MOLECULES =
consists of rod portion
and two myosin heads - CONTRACTION = attachment site = binded by head
Myosin Molecules
consists of rod portion
and two myosin heads
Contraction
attachment site = binded by head
Properties of Myosin Heads
- binds active sites of actin molecules to form cross bridges to contract the muscles
- head binds to rod portion by a hinge region that bends and straightens during contraction
- breaks down ATP
Sarcomeres
- structural and functional unit of muscles
- smallest portion of muscle that can contract
- enlarged portion = terminal cisterna = formation of TC forms a triad
- actin and myosin are arranged in highly ordered units = sarcomeres
- arrangement of myosin and actin = gives skeletal muscle its microscopic striated appearance
- each sarcomere = has a precise boundary
- extends from Z disk to the next Z disk
Z disk
- forms a stationary anchor for actin myofilaments
- connection of 1
sarcomere to another
I band
- lighter region
- actin myofilaments only
A band
- darker region
- both actin and myosin
myofilament (overlapping center except in the center)
H zone
myosin myofilament only
M line
holds myosin filaments in place
Sliding Filament Model
- muscle fiber contracts = actin and myosin myofilament = slide past one another = shorten sarcomere
- contracted or not = myosin length = doesn’t change
Relaxed Sarcomere
- H zone = visible
- actin and myosin myofilament = overlaps
slightly
Contracted Sarcomere
- H zone = disappears / no longer visible (because of pulling of actin myofilament)
- A band = same length of myosin filament = does not change
What stimulates the sarcomere to shorten
- excitability of muscle fiber
- action potential = travels from brain to spinal cord to along axons = muscle fibers = causes them to contract
Neuromuscular Junction Structure
- synapse
- every muscle = has neuromuscular junction from brain or spinal cord
- ACETYLCHOLINE = primary stimulus for action potential = inside synaptic vesicle
Do muscles have electrical properties
Yes
Ion channels
contributes to the electrical charge of both resting and stimulated cells
Gated
- most important in stimulated cell
- governs production of action potential
- has opening
- needs specific molecules to open (key)
Leak
- open
- ions (Potassium) = freely leaks out
- specific for particular ions
- resting cells = leak ion channels = allow for
slow leak of ions down their concentration gradient
Resting Membrane Potential
- negatively charged cell = more K link than Na link channels
- inside: POTASSIUM (K): dominant
- outside: SODIUM (Na): dominant
- potassium = greater (inside) to lesser
(outside) = out of cell = negative - sodium-potassium pump = responsible for maintaining balance = 2 K going in from outside and 1 Na going out from inside
Action Potential
- comes from somatic nervous system
- positively charged
- cell = stimulated = charge reverse
- GATED CHANNELS = opens because of
stimulus - inside: SODIUM (Na): dominant
- outside: POTASSIUM (K): dominant
- Na = greater (outside) to lesser (inside) =
makes charge inside positive - action potential = 1 milliseconds to few
milliseconds
Depolarization
- Na channels needs K channels to begin to open
- inward movement of Na = makes inside membrane positive
- gated channels = will only open once stimulated
Repolarization
- Na channels close and additional K channels open
- Na movement into cell stops
- K movement out of cell increases
- K channels = opens = negative charge
Muscle Contraction
- Action potential travels along an axon membrane to a neuromuscular junction
- Calcium channels open and Calcium enters presynaptic terminal
- Acetylcholine is released from presynaptic vesicle
- Acetylcholine stimulates Sodium channels on the postsynaptic membrane to open
- Na diffuses into muscle fiber, initiating action potential that travels along sarcolemma and T-tubule membranes
- Action potentials in T-tubule cause the sarcoplasmic reticulum to release Calcium
- On the actin, Calcium binds to troponin, which moves tropomyosin and exposes myosin attachment sites
- ATP molecules are broken down to ADP and P, which releases energy needed to move myosin heads
- Heads of myosin myofilaments bend, causing actin to slide past the myosin. As long as Calcium is present, the cycle repeats