Muscles: fibres, training, fatigue Flashcards

1
Q

List the 3 methods of ATP production

A

Direct phosphorylation
Glycolysis
Oxidative phosphorylation

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2
Q

Which methods of ATP synthesis provides energy the fastest ?

A

Direct phosphorylation

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3
Q

Which methods of energy production has the shortest and longest supply of energy

A

Shortest supply: direct phosphorylation

Longest supply: oxidative phosphorylation (good for endurance activities)

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4
Q

Describe direct phosphorylation, where it occurs and how long it provides energy for?

A

Involves creatine phosphate + ADP to form creatinine and ATP. Creatine is delivered to muscles via the bloodstream.

CreaTININE is a waste product which is carried way by blood tot the kidneys.

It occurs in the cytoplasm and provides energy for 10 seconds.

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5
Q

What factors limit creatine phosphate production?

A

If creatine is digested and not absorbed into the bloodstream
If creatine is absorbed but does not enter the correct cell
Creatine may not be properly modified to produce creatine phosphate.

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6
Q

Describe glycolysis, where it occurs, conditions it occurs in and how long it provides energy for?

A

Glycolysis is an anaerobic process whereby glucose is converted into 2 molecules of pyruvate. 2 ATP are used up and 2NADH and 4 ATP are produced. Net gain = 2ATP + 2NADH.

It occurs in the cytoplasm and can provide energy from 30 seconds up to 2 minutes.

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7
Q

Describe oxidative phosphorylation, including rate of energy production, where it occurs, conditions and how long it provides energy for

A

The most efficient energy production method but requires oxygen. It produces energy slowly but energy can last up to 3 hours.

Involves the:
Kreb’s cycle which occurs in the matrix of mitochondria
Electron Transport Chain: occurs in the inner membrane of the mitochondria.

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8
Q

Describe the process of oxidative phosphorylation, involving the prep step, kerb’s cycle and ETC

A

Prep step: Each Pyruvate is converted into acetyl co-enzyme A, which produces 2NADH and 2CO2.

Kreb’s cycle: acetyl co-enzyme A combines with oxaloacetate to form citric acid. This produces 1 FADH, 3NADH, 2CO2 and 1 GTP molecule.

ETC: Electron carriers migrate to inner mitochondrial membrane. High energy electrons are released from NADH and FADH and they move along the electron transport chain. Their energy is captured and used pump H+ ions across the inner membrane and into the intermembrane space.

The pumping of ions creates a build up of H+ ions in the intermembrane space. They diffuse back across the membrane through ATP synthase, generating ATP.

The electrons combine with oxygen to produce water.

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9
Q

What are the 3 main types of motor units?

A
Type 1 (slow)
Type 2a (fast fatigue resistant)
Type 2b/x (fast fatigue)
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10
Q

What are the types of motor units classified according to?

A

Speed of contraction and fatigue rate

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11
Q

How do the uses of the type 1 and 2 motor units differ?

A

Type 1: helps with endurance activities

Type 2: used for quick, short bursts of movement

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12
Q
Describe type 1 (slow) motor units according to: 
resistance to fatigue, 
oxidative capacity, 
contraction speed, 
colour,
cell contents,
motor neuron size
motor neuron conduction velocity
A
Highest resistance to fatigue
High oxidative capacity
Fastest contraction speed
Red
Many mitochondria = more aerobic capacity 
Smaller motor neurone 
Slow motor neuron conduction velocity
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13
Q
Describe type 2a (fast fatigue resistant) motor units according to: 
oxidative capacity, 
contraction speed, 
colour,
cell contents,
motor neuron size
motor neuron conduction velocity
A
Higher oxidative capacity than 2b
Slower contraction speed than type 1
Red in colour
More developed sarcoplasmic reticulum so is better at delivering calcium to muscle cells  when stimulated. 
larger motor neurone
faster motor neuron conduction velocity
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14
Q
Describe type 2b (fast fatigue) motor units according to: 
oxidative capacity, 
contraction speed, 
colour,
cell contents,
motor neuron size
motor neuron conduction velocity
A

Low oxidative capacity as they rely on aerobic glycolysis
Slower contraction speed
White - use anaerobic respiration so have low oxygen supply
More developed sarcoplasmic reticulum than type 1
Larger motor neurone size
faster motor neuron conduction velocity

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15
Q

Out of the 3 motor unit types, which one has the highest number of fibres per motor neuron?

A

Type 2a

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16
Q

What do resistance and endurance training involve?

A

Resistance: trains the body to exert maximal force for short periods of time

Endurance: training the body to to perform repetitive motions for long periods of time

17
Q

What effects do resistance and endurance training have on muscle mass and motor units?

A

Resistance: increases muscle mass, hypertrophy of type 2a ALWAYS but 2b SOMETIMES

Endurance: muscle mass can reduce, hypertrophy of type 1 motor units

18
Q

define fatigue

A

Inability to maintain power output and is reversible by rest

19
Q

Explain the causes of high intensity fatigue

A

Accumulation K+ ions inside T-tubules: This is caused by the high firing frequency of muscle action potentials. The accumulation leads to T-tubule failure, making them inexcitable and calcium is not released. As a result, there is a failure to generate force at cross bridges and excitation contraction coupling is impaired.

Accumulation of intracellular metabolites (ADP, Pi, H+) inhibits Ca release and re-uptake in SR. This inhibits cross-bridge formation. H+ also competes with calcium for troponin binding. Out of all the metabolites, the inhibition is mainly due to accumulation of Pi.

20
Q

Explain the causes of endurance fatigue

A

Central fatigue: there are inputs to the motor cortex from metabolically sensitive nerve endings which detect oxygen and hydrogen concentrations. When the muscle begins to fatigue, the drive to the muscle must also slow down. Therefore, the muscle signals to the brain to reduce the excitability of the motor cortex.

Glycogen depletion: glycogen supplies most of the energy for contraction during endurance training. As glycogen stores decrease, there is the onset of fatigue.

Pi and ADP release: these metabolites inhibit cross bridge formation and calcium release and reuptake into the SR

21
Q

After glycogens stores are depleted what is used as energy source and how is this made possible?

A

After glycogen stores are depleted, lipid stores are used as an energy source. Hormone sensitive lipase is needed to break down triglycerides into fatty acids and glycerol.

22
Q

what are the 2 phases of resistance training and what order do they occur in?

A

First: Neural
Second: Hypertrophic

23
Q

Describe the neural phase of resistance training

A

Increased recruitment of largest motor units and higher maximal firing rates

24
Q

Describe the hypertrophic phase of resistance training

A

Increase in muscle size. Starts with development of new contractile filaments added laterally to existing myofibrils. Later there is fibril splitting, where the most enlarged fibrils divide longitudinally and the fibrils become numerous

Better motor unit activation
Less antagonist activation
Improved glycolytic metabolism

25
Q

Discuss the hormonal changes that occur in resistance training

A

Increase in growth hormone, insulin-like growth factor, testosterone

26
Q

Describe the physiological changes that occur as a result of endurance training

A

Cardiovascular adaptations: increased stroke volume, cardiac output, decreased heart rate and blood pressure

Capillarisation: increased number of blood capillaries supplying each muscle

Improved metabolic performance: improved enzyme concentrations, more mitochondria, improved oxygen supply, more myoglobin, enhanced oxidative metabolism.

27
Q

Define a motor unit

A

group of muscle fibres that are innervated by a single motor neuron

28
Q

What is the functional unit of motor control?

A

Motor unit

29
Q

What is the difference between central and peripheral fatigue?

A

Central: occurs within the nervous system
Peripheral: within muscle fibres