Muscarinic Antagonists

Question 0

Effect of muscrinic antagonists

Answer 0

1. Faster heart rate
2. Sedation
3. Dry mouth
   . They block all muscrinic effects with equal efficacy
   . There r some quantitative differences in effect

Question 1

Mechanism of action

Answer 1

Muscrinic antagonists compete with acetylcholine for access to muscrinic receptors and block acetylcholine effect.

Question 2

What r the 3 main types of muscrinic antagonists?

Answer 2

Atropine
Glycopyrolate
Scopolamine

Question 3

Atropine

Answer 3

. Tertiary structure, can cross blood brain barrier
. Large doses can affect CNS 1-2 mg
. Dose:
. Bradycardia: 0.02 mg/ kg peds
Max 0.5 mg
Adults: 0.5 mg 3-5
Min prn
. A systole: 1mg 3-5 min up to 3 max