Cholinestrase Inhibitors

Question 0

What are they use for

Answer 0

1. To reverse neuromuscular blockade

2. To treat myasthenia gravis

Question 1

Function:

Answer 1

1. Impair the inactivation of acetylcholine by cholinestrase enzyme and sustain cholinergic agonism at nicotinic and muscrinic receptors

Question 2

Most prominent side effect of anticholinestrase drugs

Answer 2

Bradycardia

Question 3

Most commonly used cholinestrase inhibitors

Answer 3

Neostigmine
physiostigmine
pyridostigmine
endorphonium

Question 4

What r the other functions of Cholinestrase inhibitor besides increasing the concentration. Of acetylcholine at the neuromuscular junction

Answer 4

1. Stimulate intestinal function

2. Applied topically to eye as miotic

Question 5

Echothiophate iodide

Answer 5

1. Topical cholinestrase inhibitor
2. Irreversibly binds cholinestrase
3. Can interfere with metabolism is succinylcholine as it impairs the function of pseudocholiestrase enzyme as well

Question 6

Neostigmine

Answer 6

1. Trade name: bloxiverz
2. Vial: 10mg/ 10 ml
3. Pediatric and adult dose: 0.05mg/kg
   (0. 03-0.07 mg/ kg)
4. Effect: increase intestinal and skeletal tone, increase salivary and sweat gland secretion
5. Cholinestrase inhibitor–> increases acetylcholine concentration at neuromuscular junction
6. Side effect: bradycardia

Question 7

Physiostigmine

Answer 7

1. Vial:1 mg/ml
   2.dose: pediatric: 0.02 mg/ kg
   Adult: 0.5-1 mg/ kg
   Repeat every 10-30 min
   Max: 5 mg/ kg