Multiple Sclerosis and demielinating diseases Flashcards
Lumbar puncture in multiple sclerosis:
a. oligoclonal bands, positive in CSF, negative in serum
b. oligoclonal bands negative in fluid, positive in serum
c. lymphocytosis in the lymph fluid
d. hypoproteinorachia
e. albumin-cytological dissociation
a. oligoclonal bands, positive in CSF, negative in serum
Not applicable to multiple sclerosis:
a. women get sick more often than men
b. the average age at disease onset is about 30 years
c. the prevalence of the disease is the same worldwide
d. the risk is about 5% if a first-degree relative has the disease
c. the prevalence of the disease is the same worldwide
There is no pathological feature of multiple sclerosis:
a. spongiform degeneration of the cerebellum
b. plaques of demyelination in the white matter
c. perivascular mononuclear infiltrate in the CNS
d. axon collapse in the central nervous system
a. spongiform degeneration of the cerebellum
Rarely seen in the clinical picture of multiple sclerosis:
a. Pareses
b. Optic neuritis
c. sensory disturbances
d. hemianopsia
d. hemianopsia
Progressive multiple sclerosis will be treated with:
a. corticosteroids
b. cytostatics
c. human immunoglobulins
d. interferon beta
b. cytostatics
The most characteristic finding in the liquor of multiple sclerosis is:
a. Increased protein concentration
b. increased cell count
c. elevated IgG index (=(IgGi /albumini )/(IgGs /albumins ); elevated: > 0,7)
d. oligoclonal bands present
d. oligoclonal bands present
The relapsing-remitting form of multiple sclerosis will be treated with:
a. corticosteroids
b. cytostatics
c. human immunoglobulins
d. interferon beta
d. interferon beta
Neuromyelitis is not covered by optics:
a. eponym is Devic’s disease
b. neuromyelitis optica affects the optic nerves and spinal cord
c. neuromyelitis is a demyelinating disease of the central nervous system
d. myelitis in the syndrome is usually partial with predominantly
sensory fibre involvement
d. myelitis in the syndrome is usually partial with predominantly
sensory fibre involvement
A 70-year-old gentleman has difficulty walking (ataxic), is forgetful. On
examination, hyperreflexia of the upper and lower limbs is found, positional
sensitivity is also disturbed (+ there was something else). What is it:
a. Parkinson’s disease
b. Alzheimer’s disease
c. multiple sclerosis
d. subacute combined degeneration of the spinal cord
e. diabetic polyneuropathy
d. subacute combined degeneration of the spinal cord
Acute disseminated encephalomyelitis (ADEM) is not covered:
a. vaccination occurrences
b. occurs after infection
c. is more common in adults than in children
d. is a monophasic disease of the central nervous system
c. is more common in adults than in children
Neuromyelitis optica is caused by antibodies:
a. against aquaporin
b. against Na/K/Ca - tubules
a. against aquaporin
Lhermitis sign (in a third of patients) means:
a. electrification along the spine and upper limbs when moving the head
b. worsening of neurological symptoms from fever
c. visual impairment with fatigue
d. tonic, recurrent limb cramps
a. electrification along the spine and upper limbs when moving the head
In MS only rarely will we find:
a. depression
b. erectile dysfunction
c. handicap
d. paraplegia
d. paraplegia
The characteristic micturition disturbance of a Th5 demyelinating plaque is absent:
a. Emergency
b. atonic bladder (reduced tone)
c. frequency
d. detrusor-sphincter dyssynergy
b. atonic bladder (reduced tone)
That would be LMN disease
How do we treat a hyperexcitable bladder in MS?
a. anticholinergics (oxybutynin, imipramine, tolterodine)
a. anticholinergics (oxybutynin, imipramine, tolterodine)
What do “black holes” on MRI in MS mean?
a. demienilisation
b. inflammation
c. axonal collapse (this indicates the presence of irreversible neurological
signs causing more severe impairment)
c. axonal collapse (this indicates the presence of irreversible neurological
signs causing more severe impairment)
What is the most effective treatment for fatigue in MS?
a. amantadine
b. interferon beta
c. betacarotene
a. amantadine
The minimum information we need to diagnose MS is:
a. MR
b. evoked potentials
c. Liquor examination
d. EMG
e. clinical examination of the pupils
d. EMG
There is no side effect of interferon beta:
a. Chest pain
a. Chest pain
NU azathioprine:
a. osteoporosis
b. liver damage
c. gastric ulcer
d. hypertension
b. liver damage
An MS epidemic has been described at:
a. Faroe Islands
a. Faroe Islands
ADEM-specific test results include:
a. extensive symmetrical changes on head MRI in both hemispheres
b. meningitic fluid
c. Negative oligoclonal bands in the lymphocyte after remission of the disease
d. all of the above
d. all of the above
Which country has the highest prevalence of MS:
a. Australia
b. Slovenia
c. Austria
d. Scotland
d. Scotland
What is not true:
a. with relapsing-remitting form, multiple sclerosis starts in 85% of patients
b. a clinically isolated syndrome always leads to MS
c. the primary progressive form is relatively more common in middle-aged men
d. after 10 years of disease, the relapsing-remitting form progresses
to the secondary progressive form of MS in 50% of patients
b. a clinically isolated syndrome always leads to MS
In a patient with MS, we will find:
a. oligoclonal strips
a. oligoclonal strips
Which medicine is not given for symptomatic treatment of MS?
a. interferon beta
b. NSAIDS
c. baclofen
d. botulinum
a. interferon beta