Multiple Sclerosis Flashcards

1
Q

What is the definition of a spinal cord injury?

A

A disruption to the spinal cord
(usually due to trauma)
A cauda equina injury is a disruption to the nerve roots that lie with in the spinal column

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2
Q

What are congenital causes of spinal cord injury?

A

Spina bifida
Birth trauma
spinal muscular atrophy
congenital spinal anomaly

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3
Q

What are acquired causes of spinal cord injury?

A
Trauma - Vehicles, falls etc.
Infection - bacterial
Inflammatory
Metabolic
Degenerative
Vascular - arterial, venous
Tumour - benign, malignant
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4
Q

What type of paralysis can a cervical lesion (C1-T1) cause?

A

Tetraplegia - loss of all 4 limbs

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5
Q

What type of paralysis can a thoracic lesion (T2-L5) cause?

A

Paraplegia - loss of legs

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6
Q

What is the AISA impairment scale and what does it mean?

A

A (Complete) - No motor or sensory function is preserved
B (Incomplete) - Sensory but not motor function is preserved
C (Incomplete) - Motor function preserved and more than half of key muscles have muscle grade less than 3
D (Incomplete) - Motor function preserved and at least half of key muscles have muscle grade less than 3

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7
Q

What are the descending motor tracts?

A

Lateral corticospinal

Anterior corticospinal

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8
Q

What are the ascending motor tracts?

A

Dorsal columns
Anterolateral spinothalamic
Spinocerebellar

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9
Q

What are excessive vagal stimulation?

A

lesions ABOVE T6
stimulation of the right vagus nerve
Loss of parasympathetic control
Overwhelming vagal output - Bradycardia, Asystole
Prevent with atropine prior to intubation, suctioning

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10
Q

What is autonomic dysreflexia?

A

lesions ABOVE T6
syndrome causing acute, uncontrolled hypertension
Before it occurs there are symptoms such as:
Bladder distension, constipation
Skin, soft tissue, bony injuries
Symptoms include:
headache, hypertension, facial flushing

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11
Q

What is the management of acute spinal cord injury?

A
Bed rest/positioning/skull traction
Prevent further damage to spinal cord
Skin care
Bladder and bowel care
Prevention of thromboembolic and GI complications
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12
Q

What are the chronic complications that can occur after spinal injury?

A

Progressive neurological decline:
Syringomyelia - longitudinal cavities form in the cervical region of the spinal cord
Pain and spasticity
Rheumatological complications:
Degenerative joint disease
Hetertopic ossification - presence of bone in soft tissue where bone normally does not exist

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13
Q

What is optic neuritis?

A

Inflammation of the optic nerve
Causes pain and loss of vision
Frequently not visible (retrobulbar)

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14
Q

What is the treatment for optic neuritis?

A

High dose steroids speed up rate of recovery but have no effect on final acuity

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15
Q

What is transerve myelitis?

A
Inflammation inside the spinal chord
Often mild with good prognosis
Often pure sensory
Lhermittes phenomenon -  electrical sensation that runs down the back and into the limbs
May affect bladder
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16
Q

When is it clinically definite MS when it involves Optic neuritis and transverse myelitis?

A

Optic neuritis and transverse myelitis at different times

17
Q

What is MS?

A

MS is a disease of the central nervous system (CNS)
An inflammatory reaction in the CNS causes loss of myelin and slowing of nerve conduction
Areas of demyelination
Loss of axons

18
Q

What is the collective name of the drugs used to treat MS?

A

Disease modifying treatments e.g.

Interferon beta 1-a/b