Multiple Sclerosis Flashcards

1
Q

what is MS?

A

a chronic, progressive, degenerative disease of the CNS

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2
Q

what is MS characterized by?

A

segmental demyelination of nerve fibers of brain and spinal cord

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3
Q

what is the cause?

A

unknown

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4
Q

cause is related to?

A

genetics, infection, immunity

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5
Q

affects mostly who?

A

women between 20-50

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6
Q

MS is similar to cancer how?

A

periods of exacerbation and remission

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7
Q

more progressive when?

A

diagnosed at age 50 +

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8
Q

most prevalent in people of what ancestry

A

northern European

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9
Q

primary problem with MS

A

autoimmune process

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10
Q

possible factors include

A

-infection
-smoking
-physical injury
-emotional stress
-pregnancy
-poor state of health

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11
Q

3 pathologic processes that characterize MS

A

-chronic inflammation
-demyelination
-gliosis (scarring) in the CNS

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12
Q

immune system attacks the what?

A

myelin sheath

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13
Q

4 patterns of MS

A

-relapsing-remitting
-primary-progressive
-secondary-progressive
-progressive-relapsing

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14
Q

onset of disease is ?

A

gradual

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14
Q

clinical manifestations overview

A

-vague symptoms intermittently over months - years
-dz diagnosed long after 1st onset
-chronic progressive deterioration in some pts
-remissions and exacerbations in others
-overall = progressive deterioration in neuro function
-symptoms vary

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15
Q

s/s

A

-visual
-motor
-sensory
-cerebellar
-bowel, bladder, sexual
-cognitive
-emotional

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16
Q

sensory manifestations

A

-numbness and tingling
-pain
-tremor
-decreased hearing, vertigo, tinnitus
-chronic neuropathic pain
-lhermittes sign

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17
Q

motor manifestations

A

-weakness/paralysis of limbs and trunk
-spasticity of muscles
-scanning of speech

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18
Q

impaired bowel/bladder functions

A

-constipations
-variable urinary problems
-spastic bladder
-flaccid bladder

19
Q

sexual dysfunction

A

-ED
-decreased libido
-painful sex

20
Q

cognitive manifestations

A

-short term memory
-information processing
-attention, planning
-visual perception
-word finding

21
Q

is there a definitive test to diagnose?

22
Q

what is diagnosis based on?

A

hx, clinical manifestations, and results of diagnostic tests

23
Q

what diagnostic tests can be done?

A

-MRI
-CSF analysis
-evoked potential studies
-neuropsychological testing
-sexual hx

24
for diagnosis of MS, there must be
-2 inflammatory demyelinating lesions in at least 2 different locations -damage or an attack occurring at diff times (usually >1 mo. apart) -all other diagnoses ruled out
25
is there a cure for MS?
NO
26
goal of treatment
delay progression of dz, manage symptoms, treat acute exacerbations
27
what do dz modifying drugs do? (DMD)
-decrease frequency and severity of relapses -reduce development of brain lesions -decrease future disability
28
DMD I
-drugs that suppress immune system to modify dz progression, prevent relapses
29
immunomodulators
-treatment should begin as soon as diagnosed -modify dz progression and prevent relapses
30
interferon beta
SQ -reduces frequency and severity of attacks -reduces # and sizes of lesions -delays progression of disability
31
interferon beta adverse effects and drug interactions
-flu-like reactions -hepatotoxicity -myelosuppression -injection site reactions -depression -suicidal thoughts -drug interactions
32
how is interferon beta dispenses
single use syringe/vials
33
dz modifying drugs II
immunosuppressant mitoxantrone and cladribine
34
mitoxantrone and cladribine
-more toxic than immunomodulators -produce greater suppression of immune function
35
mitoxantrone therapeutic use
decreases neurologic disability and clinical relapses
36
mitoxantrone adverse effects and drug interaction
-myelosuppression -cardiotoxicity -fetal harm -reversible hair loss, injury to GI mucosa, n/v, amenorrhea, allergy symptoms, blue/green tint to urine and sclera
37
drugs used to manage exacerbations
corticosteroids - methylprednisone, prednisone
38
corticosteroids -
-helpful in treating acute exacterbations -reduce edema and acute inflammation at site of demyelination
39
other drug that can help with exacerbations
therapeutic plasma exchange and IV immunoglobulin G
40
MS symptoms - drugs can be used to manage these
-bladder dysfunction -bowel dysfunction -depression -fatigue -spasticity -neuropathic pain -improved walking -dizziness and vertigo
41
MS nursing interventions
-promote physical mobility -prevent injury -enhance bowel and bladder control -enhance communication -improve sensory and cognitive function -teach about meds -educate family
42
want pt to -
-maximize neuromuscular function -maintain ADLs -manage fatigue -optimize psychosocial well-being -adjust to illness -decrease factors that precipitate exacerbations
43
what kind of tremor?
intention tremor
44