Multiple Organ Dysfunction Syndrome (MODS)

Question 1

is altered organ function in an acutely ill patient
that requires medical intervention to support
continued organ function.

isn’t an illness itself; rather, it’s a
manifestation of another progressive, underlying condition

Answer 1

Multiple organ dysfunction syndrome (MODS)

Question 2

■ Multiple trauma
■ Massive infection or sepsis
■ Hemorrhage or shock
■ Surgical complications
■ Acute pancreatitis
■ Burns, extensive tissue damage, and/or necrotic
tissue
■ Aspiration
■ Multiple blood transfusions
■ Inadequate fluid resuscitation

Answer 2

Those at high risk for developing MODS

Question 3

Clinical manifestations two patterns:
which occurs most often when the initiating event is a
pulmonary one such as lung injury, the patient experiences
respiratory compromise that necessitates intubation. This
usually occurs within 72 hours of the initiating event.
- organ or organ system failure is due to a
direct injury such as trauma or a primary disorder that
usually involves the lungs, such as pneumonia, aspiration,
near drowning, and pulmonary embolism.

Answer 3

Primary Mods

Question 4

• It occurs most often in the patient with septic shock and
progressively unfolds over about 1 month.
• The patient also experiences respiratory failure and requires
intubation.
• The patient remains hemodynamically stable for about 7 to 14 days.
• Despite this apparent stability, the patient exhibits a hypermetabolic
state characterized by hyperglycemia, hyperlacticacidemia, and
polyuria.
• The metabolic rate is 1.5 to 2 times basal metabolic rate.
• During this stage, there is a severe loss of skeletal muscle mass
(autocatabolism).
• The organ system failure is due to sepsis.

Answer 4

Secondary MODS

Question 5

• Vasodilation and decreased PVR with normal BP
• CO increases to maintain BP
• Hypovolemia due to capillary permeability &
  interstitial fluid loss
• Skin: warm, pink & dry
• Chills & body temp.
• Hyperventilation
• resp. alkalosis

Answer 5

Assessment of
Early MODS

Question 6

• Hypotension
• Weak thready pulse
• ECG: ST & T – waves changes (myocardial
  perfusion)
• Skin: cold, moist, pale, mottling cyanosis
• Hematologic alterations
• Hypoxia
• Metabolic acidosis

Answer 6

Assessment:
Late MODS