Multiple Myeloma Flashcards
1
Q
Igs
A
Get monoclonal M spike on serum protein electrophoresis. Most commonly IgG, can be IgA
2
Q
Associated Disease
A
Primary amyloidosis
3
Q
Presentation
A
CRAB:
HyperCalcemia (cytokines stimulate osteoclast activation)
Renal insufficiency
Anemia
Bone lytic lesions (punched out)/back pain
4
Q
Urine Findings
A
Bence Jones proteins (Ig light chains)
5
Q
RBC Formation
A
Rouleaux formation
6
Q
Histo Appearance
A
Monoclonal plasma cell (“fried egg” appearance)
7
Q
MGUS
A
Monoclonal expansion of plasma cells, asymptomatic, that can lead to MM. No CRAB findings or end organ damage. Monitor
8
Q
Waldenstrom Macroglobulinemia
A
NOT MM
M spike of IgM leading to hyperviscosity syndrome (blurred vision, Raynaud) but no CRAB findings
