Leukemia Flashcards
ALL Age, Association, histo, 2 markers, prognosis/genetics
Less than 15 years, young
Down syndrome
Super increased lymphoblasts in blood and marrow
TdT+ and CD10+
Very responsive to therapy, t(12:21) better prognosis
CLL Age, Epi, 2 Markers, Progression, Histo, Association
Old old. Most common adult leukemia CD20+ and CD5+ (Bc) Often asymptomatic and progresses slowly so just monitor Smudge cells in peripheral blood AIHA (warm or cold)
S(small)LL
Same as CLL except CLL has increased peripheral blood or bone marrow involvement
AML Age, 2 Histo, Important subtype, common presentation
50-60, older adults
Auer rods and a lot of circulating myeloblasts
M3 subtype is t(15;17) and responds to Vitamin A
DIC is common presentation
CML genetics, what it really is/findings/progression, tx
Philadelphia chromosome t(9;22), BCR-ABL
Myeloid stem cell proliferation with increase in a lot of mature myeloid cells, notably BASOPHILS
Can increase to “blast crisis” of AML or ALL
Responds to imatinib, inhibitor of bcr-abl tyrosine kinase
CLL Age, Epi, 2 Markers, Progression, Histo, Association
Old old. Most common adult leukemia CD20+ and CD5+ (Bc) Often asymptomatic and progresses slowly so just monitor Smudge cells in peripheral blood AIHA (warm or cold)
S(small)LL
Same as CLL except CLL has increased peripheral blood or bone marrow involvement
AML Age, 2 Histo, Important subtype, common presentation
50-60, older adults
Auer rods and a lot of circulating myeloblasts
M3 subtype is t(15;17) (Down syndrome associated) and responds to Vitamin A
DIC is common presentation
CML genetics, what it really is/findings/progression, tx
Philadelphia chromosome t(9;22), BCR-ABL
Myeloid stem cell proliferation with increase in a lot of mature myeloid cells, notably BASOPHILS
Can increase to “blast crisis” of AML or ALL
Responds to imatinib, inhibitor of bcr-abl tyrosine kinase
