Lymphoma

Question 1

Hodgkin vs. NH Lymphoma (location, prognosis, histo, demographic, associations, constitutional symptoms)

Answer 1

Painless localized in single group of nodes (usually neck) with contiguous spread vs. multiple peripheral nodes with noncontiguous
Better vs. worse
Reed-Sternberg cells vs. majority with B cells, except those with T cell origins
Bimodal (young adulthood and elderly) and usually men (except nodular sclerosing) vs. around 20-40
Strongly associated with EBV vs. maybe HIV and autoimmunes
Has B symptoms vs. fewer constitutional symptoms

Question 2

Hodgkin vs. NH Lymphoma (location, prognosis, histo, demographic, associations, constitutional symptoms)

Answer 2

Painless localized in single group of nodes (usually neck) with contiguous spread vs. multiple peripheral nodes with noncontiguous
Better vs. worse
Reed-Sternberg cells vs. majority with B cells, except those with T cell origins
Bimodal (young adulthood and elderly) and usually men (except nodular sclerosing) vs. around 20-40
Strongly associated with EBV vs. maybe HIV and autoimmunes
Has B symptoms vs. fewer constitutional symptoms

Question 3

Reed-Sternberg Cells (appearance, 2 markers/origin, prognostic)

Answer 3

Giant tumor cell in HL, binucleate or bilobed with the 2 halves as mirror images (“owl eyes”)
CD15+ and CD30+ B-cell origin
More RS is worse prognosis, more lymphocytic reaction against RS cells is better

Question 4

Reed-Sternberg Cells (appearance, 2 markers/origin, prognostic)

Answer 4

Giant tumor cell in HL, binucleate or bilobed with the 2 halves as mirror images (“owl eyes”)
CD15+ and CD30+ B-cell origin
More RS is worse prognosis, more lymphocytic reaction against RS cells is better

Question 5

Nodular Sclerosing Subtype (what it is, prognosis, demographic)

Answer 5

Most common HL, with nodules separated by sclerosing bands, few RS so good px, mainly young and MEN AND WOMEN EQUALLY

Question 6

Lymphocyte Rich Form

Answer 6

Least common, younger males, few RS, best prognosis

Question 7

Lympocyte Mixed Form

Answer 7

2nd most common, bad prognosis

Question 8

Lympocyte Depleted Form

Answer 8

Increased ratio of RS/lymphocyte, worst px

Question 9

Burkitt Lymphoma (demographic, genetic, histo, association, classic presentation)

Answer 9

Adolescents/young adults
t(i:14) - constitutively active c-myc
Starry sky appearance - lymphocytes with macrophage “stars”
Associated with EBV
Jaw lesion in endemic form in Africa, pelvis or abdomen sporadically

Question 10

Burkitt Lymphoma (demographic, genetic, histo, association, classic presentation)

Answer 10

Adolescents/young adults
t(i:14) - constitutively active c-myc
Starry sky appearance - lymphocytes with macrophage “stars”
Associated with EBV
Jaw lesion in endemic form in Africa, pelvis or abdomen sporadically

Question 11

Most Common NHL in Adults

Answer 11

Diffuse large B-cell lymphoma

Question 12

Follicular lymphoma Translocation

Answer 12

t(14;18) - BCL-2 active

Question 13

Mantle Cell Lymphoma Translocation

Answer 13

t(11;14) - cyclin D1

Question 14

Marginal Cell MALToma 3 Associations

Answer 14

Sjogren’s, Hashimoto’s, H. pylori

Question 15

Intestinal T-Cell Lymphoma

Answer 15

NHL associated with long term Crohn’s

Question 16

Mycosis fungoides/Sezary syndrome

Answer 16

Cutaneous T cell lymphoma/progressed to leukemia. Presents as skin patches and plaques